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ART-Pro: Clinical Trial Evaluating Biparametric MRI and Advanced, Quantitative Diffusion MRI for Detection of Prostate Cancer
Advanced Restriction Imaging and Reconstruction Technology for Prostate MRI (ART-Pro)
Who can join
Ages 18 and older · Men
Full eligibility criteria
Inclusion Criteria: * 18 years of age or older * Referred for mpMRI of the prostate for suspicion of prostate cancer * MRI is conducted using the standardized ART-Pro acquisition protocol Exclusion Criteria: * Currently incarcerated * Previous diagnosis of prostate cancer * Active non-prostate tumor(s) in structures of the body near the prostate * Previous prostate surgery * History of hip implant * Metal implants or implanted devices in the body or other criteria that are deemed to require deviation from the usual acquisition protocol or scanning procedures
About the study
This is a multicenter, multinational trial to evaluate advanced MRI techniques for improved detection of clinically significant prostate cancer (csPCa). The study will enroll 500 participants at 5 clinical centers (100 participants per center). The current standard MRI technique for prostate cancer screening is multiparametric MRI (mpMRI), but two drawbacks include need for intravenous (IV) contrast and dependence on radiologist expertise. The investigators expect that the combination of two other techniques, biparametric MRI (bpMRI) and Restriction Spectrum Imaging restriction score (RSIrs), will help non-expert radiologists achieve similar performance to expert radiologists using bpMRI or mpMRI for detection of csPCa, while avoiding the drawbacks that are present when using mpMRI.
What is being tested
- RSI MRI (diagnostic test)
Sponsor: University of California, San Diego · Participants: 500 · Started: Dec 15, 2023
Contact the study team
- Tyler Seibert, MD, PhD · Phone: 858-246-2180
Official record on ClinicalTrials.gov — NCT06579417
Locations in the U.S.
| California | University of California San Diego, San Diego University of California, San Francisco, San Francisco (Not yet recruiting) |
| Massachusetts | Massachusetts General Hospital, Boston (Not yet recruiting) |
| New York | Weill Cornell Medical College, New York (Not yet recruiting) |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.