Home › Aortic Valve Stenosis › NCT06595407
Loss of Y Chromosome in Aortic Stenosis
Who can join
Ages 40 and older · Men · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Aortic stenosis (valve area \<1.5cm2) Exclusion Criteria: * Bicuspid aortic valve * History of radiation to chest * Inflammatory (autoimmune, rheumatologic) disease associated with aortic stenosis * Active cancer
About the study
The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure and need for valve replacement procedures (including surgery and catheter-based replacement). Aortic stenosis has a strong male predominance. The purpose of this study is to evaluate whether loss of Y-chromosome from circulating blood cells in males, which has been associated with TGF-beta-related fibrosis of other organs, is associated with the development of aortic stenosis.
What is being tested
- Blood analysis for loss-of-Y chromosome (diagnostic test)
Sponsor: University of Virginia · Participants: 200 · Started: Aug 15, 2024
Contact the study team
- Jonathan R Lindner, MD · Phone: 434 2979442
- Bethany Gholson · Phone: 4342979444
Official record on ClinicalTrials.gov — NCT06595407
Locations in the U.S.
| Virginia | University of Virginia, Charlottesville |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.