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The Gut-Brain Axis During Neurorehabilitation; Prebiotic Treatment to Alter the Gut Microbiome and Neurologic Symptoms
RecruitingHealthy volunteers welcome
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Brain Injury Patients Inclusion * Ages 18 and above * Admitted to Moody Neurorehabilitation Institute for care * Less than 6 months post-injury * English speaking * Must be able to eat and drink by mouth * Willing and able to comply with study procedures * Willing and able to provide consent (with LAR if needed) Exclusion * Significant heart, liver, kidney, blood or respiratory disease * HIV, Hepatitis B or Hepatitis C * Pregnancy or becoming pregnant during the study * History of inflammatory bowel disease * History of celiac disease * Active diverticular disease * Known allergy to study agent * Any medical condition that, in the opinion of the investigator, would place the subject at increased risk for participation Community Control Subjects Inclusion * Ages 18 and above * Have a family member who is admitted to Moody Neurorehabilitation Institute for care OR is working at Moody Neurorehabilitation Institute * English speaking * Willing and able to comply with study procedures * Willing and able to provide consent * FACs score ≤ 50 Exclusion * Trauma to head in last 6 months * Stroke in last 6 months * Significant heart, liver, kidney, blood or respiratory disease * HIV, Hepatitis B or Hepatitis C * Pregnancy or becoming pregnant during the study * History of inflammatory bowel disease * History of celiac disease * Active diverticular disease * Any medical condition that, in the opinion of the investigator, would place the subject at increased risk for participation
About the study
The aim of this study is to characterize the microbiome of patients undergoing post-acute residential neurorehabilitation compared to community controls and to determine if a dietary fiber, Inulin, can create a shift in the microbiome leading to changes in fatigue and cognition.
What is being tested
- Inulin (dietary supplement)
Sponsor: The University of Texas Medical Branch, Galveston · Participants: 130 · Started: Mar 6, 2025
Contact the study team
- Kate Randolph, BS · Phone: 409-772-8126
- Christopher Danesi, MS · Phone: 409-772-8126
Official record on ClinicalTrials.gov — NCT06607523
Locations in the U.S.
| Texas | University of Texas Medical Branch, Galveston |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.