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Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength
BCCMA: Recovery of Aged Muscle After Disuse Atrophy (REMEDY): Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength (EMPHASIS)
Who can join
Ages 55 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Age \> 55 years * Diagnosis of stage 3-4 CKD or an eGFR of \<45 mL/min/1.73m2 Exclusion Criteria: * Cardiovascular risk: Poorly controlled hypertension (\>160/100) * Coronary event in past 6 months * Class III or IV CHF * symptomatic angina at rest or during exercise * Syncope in past year, without known resolution of cause * COPD requiring home oxygen * Contraindications to resistance training, including history of intracranial or retinal bleeding; Diabetes with active proliferative retinopathy * History of significant spinal osteoarthritis or spinal stenosis * Dementia (on medical record review or mini-mental status exam score)
About the study
The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness. The problem of hospital-acquired weakness is greatly increased in at-risk Veteran populations such as those with chronic kidney disease (CKD). The purpose of this collaborative study involving Denver and Baltimore VAMC sites is to improve health through the detection and rehabilitation management of hospital-acquired weakness in those with CKD. The study goals include identifying and monitoring the optimal muscle assessment sites in clinical settings, examining how muscle health impacts length of hospital stay and physical resilience, and determining how home-based and supervised exercise comparatively addresses post-hospitalization physical resilience using performance tests and Veteran feedback.
What is being tested
- Exercise (other)
Sponsor: VA Office of Research and Development · Participants: 250 · Started: Apr 11, 2025
Contact the study team
- Michael Harris-Love, DSc MPT BS · Phone: (720) 857-2802
- Katie Boncella, MS · Phone: (303) 724-0687
Official record on ClinicalTrials.gov — NCT06607913
Locations in the U.S.
| Colorado | Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora |
| Maryland | Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.