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AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance

RecruitingHealthy volunteers welcome

AMD and Validating Rod-Meditated Dark Adaptation With Everyday Task Performance

Who can join

Ages 50 to 89 · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* Capable and willing to provide consent
* Has been diagnosed with early, intermediate dry age-related macular degeneration or geographic atrophy or has a healthy macular for controls
* At least 50 years of age

Exclusion Criteria:

* Unable or unwilling to give consent or unable to read consent since the study involves testing which requires reading
* Under 50 years of age
* Presence of dense cataracts in the study eye (s) that can affect visual function tests
* Presence of glaucoma requiring treatment during the study and/or visual field defects
* Previous retinal laser or surgical therapy in the study eye(s)
* Previous retinal laser or surgical therapy in the study eye(s)
* Any other ocular condition requiring long-term therapy or surgery during the study
* The participant has photographically significant corneal or media opacities in either eye that would preclude adequate ophthalmic imaging and functional testing
* Diagnosis of nystagmus that will interfere with testing
* High myopia -8 Diopters or more severe
* The participant has, in the opinion of the Investigator, any physical or mental condition that would increase the risk of participation in the study or may interfere with the study procedures, evaluations, and outcome assessments.

About the study

The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark adaptation and reading performance under dim illumination, both which depend on rod photoreceptors.

What is being tested

Sponsor: Duke University · Participants: 100 · Started: Aug 15, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT06619405

Locations in the U.S.

North CarolinaDuke Eye Center, Durham

Conditions

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.