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Circadian Mechanisms, Glucose, and CV Risks in T1D

Circadian Mechanisms of Glycemic Control and Cardiovascular Risk in Adults With Type 1 Diabetes

Who can join

Ages 18 to 50 · All sexes

Inclusion Criteria:

* Adults 18-50 years with a clinical diagnosis of T1D for at least one year
* Report habitual sleep irregularity ≥1 hour/week
* Desire to improve sleep, and own a smartphone (Android or iPhone)

Exclusion Criteria:

* Self-reported A1C within the past 6 months ≥10%
* insomnia symptoms defined as Insomnia Severity Index score ≥15
* history of restless leg syndrome
* history of severe hypoglycemia (defined as hypoglycemic episode that results in loss of consciousness, seizure, or requiring emergency room visit or hospitalization) within the past 6 months
* rotating shift or night work or routinely sleeping after 3 AM.
* use of sleep medications/aids, significant medical comorbidities (such as heart failure, cirrhosis, chronic obstructive pulmonary disease requiring oxygen, active treatment for cancer, on renal replacement therapy \[dialysis\])
* depression (Patient Health Questionnaire 8 \[PHQ-8\] score ≥15)
* history of stroke with neurological deficits
* pregnant, breast feeding, or planning pregnancy, as sleep and glucose are known to change during pregnancy and breastfeeding.
* Allergy to lidocaine Participants who passed the first screen by phone will be scheduled for a consenting visit at UIC

About the study

People with type 1 diabetes are disproportionately affected by cardiovascular disease (CVD). Short and irregular sleep have been associated with cardiovascular risk in this population. Improving sleep regularity has been associated with improved glycemic markers however mechanisms by which improving sleep regularity improves metabolic and cardiovascular health is not known. The investigators propose to conduct a mechanistic study using a sleep stability manipulation. This proposal will advance the understanding of mechanisms by which improving sleep regularity influences glycemic control and cardiovascular risk in T1D.

What is being tested

• Sleep stability intervention (behavioral)

Sponsor: University of Illinois at Chicago · Participants: 100 · Started: Mar 13, 2025

Contact the study team

• Pamela Martyn-Nemeth, PhD · Phone: 312-996-7903
• Sirimon Reutrakul, MD · Phone: 312-996-6060

Official record on ClinicalTrials.gov — NCT06624046

Locations in the U.S.

Conditions

• Type 1 Diabetes

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.