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Exercise Effects on the Neurobiology Underlying Stress-related Eating Behaviors in Veterans

Exercise Effects on the Neurobiology Underlying Stress-Related Eating Behaviors in Veterans

Who can join

Ages 18 to 75 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Veteran
* Body mass index (BMI) of 25 or greater
* Physically inactive
* Able to attend study visits in person in Aurora, CO

Exclusion Criteria:

* Currently pregnant
* History of bariatric surgery
* Current eating disorder
* Current treatment with appetite-altering medications (e.g., glucagon-like peptide-1 (GLP-1) agonists)
* Contraindication to MRI (weight \> 500 pounds (lbs); claustrophobia; metal or electronic devices in the body)
* Cardiovascular disease, chronic kidney disease, pulmonary disease, or diabetes
* Unable to exercise due to cardiac, pulmonary, neurologic, or orthopedic reasons

About the study

The purpose of this study is to learn more about how common lifestyle interventions, such as exercise, affect how our brains respond to performing thinking tasks and to viewing pictures of foods and various other objects. The investigators are also interested in how changes in hormones that might be different in men and women could affect how lifestyle interventions change these brain responses.

What is being tested

• Exercise (behavioral)

Sponsor: VA Office of Research and Development · Participants: 132 · Started: Sep 15, 2026

Contact the study team

• Kristina T Legget, PhD · Phone: (720) 724-5809

Official record on ClinicalTrials.gov — NCT06627569

Locations in the U.S.

Conditions

• Overweight
• Obesity

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.