Home › Hypothyroidism › NCT06629272
Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing
Who can join
Ages 65 and older · All sexes
Full eligibility criteria
Patient Eligibility: Inclusion Criteria: 1. age 65 years and older 2. on thyroid hormone therapy and have a serum Thyroid-stimulating hormone (TSH) \<0.5 mIU/L or are on thyroid hormone therapy for an inappropriate indication 3. English speaking 4. without cognitive impairment Exclusion Criteria: 1\) Patients with a diagnosis of thyroid cancer, secondary hypothyroidism, history of total thyroidectomy or hospitalization in the past 3 months will be excluded. Provider eligibility: Inclusion: Primary care physicians, endocrinologists, geriatricians, and Advanced Practice Providers (APPs) who practice at University of Michigan, Henry Ford Health System or University of California San Fransico (UCSF) and who prescribe thyroid hormone for eligible patients identified above will be eligible for study participation. Exclusion: Providers who don't prescribe thyroid hormone.
About the study
The proposed study focuses on testing a novel adapted evidence-based multilevel intervention, Deprescribing Thyroid Hormone In Older Adults (D-THIO), to support thyroid hormone deprescribing (dose de-escalation and/or discontinuation) in older adults with thyroid hormone overtreatment and/or misuse and reduce patient harm. Findings from this study will lay the groundwork for broad implementation of D-THIO and serve as a model for deprescribing inappropriate medications for other endocrine conditions and conditions with biochemical monitoring.
What is being tested
- D-THIO (Deprescribing Thyroid Hormone In Older Adults) (behavioral)
- Enhanced usual care (behavioral)
Sponsor: University of Michigan · Participants: 900 · Started: Dec 2, 2024
Contact the study team
- Brittany Gay · Phone: 734-763-8608
Official record on ClinicalTrials.gov — NCT06629272
Locations in the U.S.
| California | University of California San Francisco, San Francisco |
| Michigan | University of Michigan, Ann Arbor Henry Ford Health System, Detroit |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.