Home › Schizophrenia › NCT06641297
White Matter Plasticity in Schizophrenia
Who can join
Ages 15 to 45 · All sexes
Full eligibility criteria
Inclusion Criteria: * Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS * age 15-45 * able to provide informed consent Exclusion Criteria: * contraindications to MRI (metal implants, claustrophobia) * medical condition that limits use of hands (ie, arthritis) * Active or recent (within 6 months) substance use disorder other than nicotine
About the study
Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.
What is being tested
- Music video game (behavioral)
Sponsor: University of Maryland, Baltimore · Participants: 36 · Started: Jan 2, 2025
Contact the study team
- Joshua J Chiappelli, MD · Phone: 4104026827
Official record on ClinicalTrials.gov — NCT06641297
Locations in the U.S.
| Maryland | Maryland Psychiatric Research Center, Catonsville University of Maryland Baltimore - Maryland Psychiatric Research Center, Catonsville (Not yet recruiting) |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.