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Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction
Chronobiological Basis of Depression During the Menopause Transition
Who can join
Ages 45 to 75 · Women
Full eligibility criteria
Inclusion Criteria: * Women aged 45-75 years old * Experiencing significant down, sad or hopeless feelings that are affecting their daily life * These mood changes started or got worse during the menopause transition * Irregular or no menstrual cycle for at least 6 months * Non-smoking * Located in San Diego County Exclusion Criteria: * Untreated sleep apnea * Migraine headaches that are triggered or worsened by bright light * Currently suicidal or psychotic * History of bipolar disorder * A medical condition or job where fatigue or changes in sleep schedule could be unsafe * Planning to start, stop, or change medications in the next 4 months
About the study
\*\*Participants must live in San Diego County\*\*
The purpose of this study is to learn more about an experimental Sleep \& Light Intervention (SALI) for menopausal mood changes or depression. Researchers want to find out whether adjusting the body's internal clock-which helps regulate sleep, hormones, mood, and energy- can improve symptoms such as depression, poor sleep, and low energy during menopause.
What is being tested
- Phase Advanced Intervention (PAI) (behavioral)
- Phase Delay Intervention (PDI) (behavioral)
Sponsor: University of California, San Diego · Participants: 120 · Started: Mar 11, 2025
Contact the study team
- Jennifer A Perrott, MSW · Phone: (407) 619-9441
- David Sommerfeld, Ph.D. · Phone: (407) 966-7703
Official record on ClinicalTrials.gov — NCT06678880
Locations in the U.S.
| California | University of California San Diego Hillcrest Medical Center, San Diego |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.