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APPI-Cost Trial for Perforated Appendicitis
The APPI-Cost Trial: Cost Assessment of Povidone-Iodine Irrigation for Prevention of Intra-abdominal Abscess in Perforated Appendicitis
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Eligibility for Enrollment Inclusion Criteria: * Plan to undergo appendectomy for acute appendicitis Exclusion Criteria: * Preoperative hemodynamic instability requiring ongoing infusion of vasopressors * Allergy to iodine * Uncontrolled hyper- or hypothyroidism * Renal dysfunction * Pregnant or breastfeeding * Primary language neither English nor Spanish * Lack of functioning telephone or email account * Incarcerated or in police custody Eligibility for Randomization Inclusion Criteria: * Enrolled in study preoperatively * Intraoperative diagnosis of perforated appendicitis Exclusion Criteria: * Non-perforated appendicitis
About the study
The purpose of this study to assess the clinical effectiveness and cost-effectiveness of povidone-iodine (PVI) irrigation in perforated appendicitis, to investigate barriers and facilitators to future implementation of PVI irrigation, and to collect costs and clinical and patient-reported outcomes among patients with non-perforated appendicitis.
What is being tested
- PVI (drug)
- Usual Care (drug)
Sponsor: The University of Texas Health Science Center, Houston · Participants: 346 · Started: Apr 7, 2025
Contact the study team
- Dalya M Ferguson, MD, MS · Phone: (713) 566-5098
- Debbie Nguyen · Phone: (713) 566-5098
Official record on ClinicalTrials.gov — NCT06705842
Locations in the U.S.
| Texas | The University of Texas Health Science Center at Houston, Houston |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.