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General vs Spinal in Total Joint Arthroplasty (TJA)

General Versus Spinal Anesthesia for Total Joint Arthroplasty: A Prospective Randomized Trial

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Patients undergoing a primary total hip or knee arthroplasty
* Subjects must be capable of providing informed consent
* English or Spanish speaking

Exclusion Criteria:

Patients with contraindications for spinal anesthesia such as:

* Prior lumbar surgery with hardware insertion
* Elevated intracranial pressure
* Infection at the site of the procedure
* Thrombocytopenia or coagulopathy
* Severe mitral and aortic stenosis and left ventricular outflow obstruction
* Severe spine pathology (spinal stenosis, spondylolisthesis, spondylosis) with radiculopathy and/or neurogenic claudication
* Preexisting neurological disease

Patients with contraindications for general anesthesia such as:

* Congestive heart failure
* Severe aortic stenosis
* Patient is unable/unwilling to consent
* Current pregnancy or women planning on becoming pregnant in the next year, and women who think they might be pregnant, or women who become pregnant during the study period will be removed from the study.
* Prisoners

About the study

The purpose of this research is to compare post-operative outcomes from patients undergoing TJA. The study team wants to learn about outcomes like length of hospital stay, post-operative pain scores, post-operative nausea, deep and superficial surgical site infection, periprosthetic fracture (a broken bone that occurs around an orthopaedic implant), implant dislocation, readmission rates, and revision rates.

What is being tested

• General Anesthesia (procedure)
• Spinal Anesthesia (procedure)

Sponsor: University of Miami · Participants: 2,396 · Started: Feb 1, 2025

Contact the study team

• Victor H Hernandez, MD · Phone: 305-689-5195
• Antonio M Fernandez-Perez, MS · Phone: 305-689-5195

Official record on ClinicalTrials.gov — NCT06747494

Locations in the U.S.

Conditions

• Knee Osteoarthritis
• Hip Osteoarthritis

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.