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Full-Avoidance vs. Permissive/Regulated Drinking & Outcomes On Fibrillation
Full-Avoidance vs. Permissive/Regulated Drinking & Outcomes On Fibrillation (FULL-PROOF)
Who can join
Ages 21 and older · All sexes
Full eligibility criteria
Inclusion Criteria * Comfortable reading and writing in English * Have a smartphone and willing and able to use the Eureka mobile application * Currently diagnosed with paroxysmal AFib without a plan to change their AFib management during the two-week monitoring period * At least one episode of AFib in the past month OR, in the judgement of a healthcare provider, could potentially have one episode of AF in the next month * Drank alcohol at least 1 day/week on average in the past month * Willing and able to be randomly assigned daily to avoid or not avoid drinking alcohol over a 2-week period * Willing and able to provide written informed consent Exclusion Criteria * Only post-operative AFib * Greater than 40% ventricular pacing * History of alcohol addiction or abuse determined by self-reported history or AUDIT-C score * Intolerance to alcohol * History of liver disease * Currently incarcerated * Currently pregnant or trying to get pregnant
About the study
The goal of this study is to assess the short-term effects of minimal and moderate drinking on atrial fibrillation (AFib) episodes in a real-world population diagnosed with 'come-and-go'/paroxysmal AFib. The question it aims to answer is:
Is there a greater occurrence of AFib episodes when participants are allowed to consume alcohol according to random assignment?
Participants will:
* Be given daily random assignments to avoid or not to avoid alcohol * Wear an adhesive electrocardiographic (ECG) heart monitor * Wear a wrist-worn fitness tracker * Wear an anklet transdermal alcohol monitor * Wear an adhesive glucose monitor * Complete morning and evening surveys daily
Participants may be compensated up to $50 for full completion of the study. This study can be done in-person or remote.
What is being tested
- Alcohol Consumption Randomized Instructions (behavioral)
Sponsor: University of California, San Francisco · Participants: 100 · Started: Apr 17, 2025
Contact the study team
- Gregory M Marcus, MD, MAS · Phone: 415-476-5706
- Hannah H Oo, BS · Phone: 415-476-4999
Official record on ClinicalTrials.gov — NCT06754176
Locations in the U.S.
| California | UCSF Medical Center at Mission Bay, San Francisco UCSF Medical Center at Parnassus, San Francisco |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.