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New Mechanisms of Obesity

Pathogenic Mechanisms of Obesity and Its Cardiometabolic Complications

Who can join

Ages 15 to 22 · All sexes

Inclusion Criteria:

* Age 15 to 22 years
* In puberty (girls and boys: Tanner stage III-V);
* BMI \>85th

Exclusion Criteria:

* Pregnancy;
* endocrinopathies (e.g., Cushing syndrome);
* substance abuse;
* medications affecting insulin resistance such as metformin, GLP-1 analogues; -
* high fibers intake (\> 30g/day) as assessed by a 3-day food record.

About the study

Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition. Herein, investigators propose to elucidate the interaction between colonic fermentation and insulin resistance in modulating metabolism in youth with obesity.

What is being tested

• Lactulose Oral Product (other)

Sponsor: Yale University · Participants: 55 · Started: Nov 13, 2025

Contact the study team

• NICOLA SANTORO, MD, PhD · Phone: 2037852819

Official record on ClinicalTrials.gov — NCT06768827

Locations in the U.S.

Conditions

• Obesity
• Overweight
• Insulin Resistance

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.