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REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

RecruitingObservational study

Who can join

Ages 18 to 105 · All sexes

Full eligibility criteria
Inclusion Criteria:

* BVF of a TAV (either Medtronic or Edwards) requiring redo TAVR

Exclusion Criteria:

* BVF due solely to paravalvular regurgitation
* Active endocarditis
* Untreated acute valve thrombosis
* Life-expectancy less than 1-year
* Subject is less than legal age of consent, legally incompetent, or otherwise vulnerable
* Participating in another study that may influence the outcome of this study

About the study

The purpose of this study is to generate clinical evidence on valve safety and performance in subjects treated by redo Transcatheter Aortic Valve Replacement (TAVR).

What is being tested

Sponsor: Medtronic Cardiovascular · Participants: 225 · Started: Feb 6, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT06777368

Locations in the U.S.

AlabamaUniversity of Alabama at Birmingham, Birmingham
ArizonaAbrazo Arizona Heart Hospital, Phoenix
CaliforniaKaiser Permanente Los Angeles Medical Center, Los Angeles
Kaiser Permanente Northern California, Sacramento
Sutter Heatlh, Sacramento
Stanford Hospital & Clinics, Stanford
Los Robles Regional Medical Center, Thousand Oaks
ColoradoMedical Center of the Rockies, Loveland
ConnecticutHartford Hospital, Hartford
Yale New Haven Hospital, New Haven
District of ColumbiaMedStar Washington Medical Center, Washington D.C.
FloridaMorton Plant Hospital, Clearwater
HealthPark Medical Center, Lee Memorial Health, Fort Myers
Orlando Health/Orlando Regional Medical Center, Orlando
Tampa General/USF, Tampa
IndianaParkview Health, Fort Wayne
Saint Vincent Heart Center of Indiana, Indianapolis
IowaMercyOne Iowa Heart Center, Des Moines
University of Iowa Hospitals and Clinics, Iowa City
KansasThe University of Kansas, Kansas City
Ascension Via Christi St. Francis, Wichita
MaineMaine Medical Center, Portland
MarylandMedstar Union Memorial Hospital, Baltimore
The Johns Hopkins Hospital, Baltimore
MassachusettsBrigham and Women's Hospital, Boston
Massachusetts General Hospital, Boston
MichiganUniversity of Michigan Health, Ann Arbor
Henry Ford Hospital, Detroit
Corewell Health (Spectrum), Grand Rapids
MinnesotaAbbott Northwestern/Minneapolis Heart, Minneapolis
Mayo Clinic, Rochester
CentraCare Heart and Vascular Center, Saint Cloud
MissouriSt. Luke's Hospital of Kansas City, Kansas City
MontanaProvidence Saint Patrick Hospital, Missoula
New HampshireDartmouth-Hitchcock Medical Center, Lebanon
Catholic Medical Center, Manchester
New JerseyJersey Shore University Medical Center, Neptune City
The Valley Hospital, Paramus
New YorkBuffalo General Medical Center, Buffalo
Northwell Health, Manhasset
Mount Sinai Hospital, New York
NYU Langone Medical Center, New York
Saint Francis Hospital, Roslyn
Montefiore Medical Center, The Bronx
North CarolinaAstrium Health Wake Forest Baptist Medical Center, Winston-Salem
OhioThe Christ Hospital, Cincinnati
University Hospitals of Cleveland Medical Center, Cleveland
OhioHealth Riverside Methodist Hospital, Columbus
OklahomaOklahoma Heart Hospital, Oklahoma City
OregonProvidence Saint Vincent Medical Center, Portland
PennsylvaniaLehigh Valley Hospital, Allentown
UPMC Pinnacle, Mechanicsburg
Allegheny General Hospital, Pittsburgh
UPMC Presbyterian, Pittsburgh
Lankenau Medical Center, Wynnewood
TennesseeSt. Thomas West Hospital, Nashville
TriStar Centennial Medical Center, Nashville
TexasAscension Seton Medical Center Austin, Austin
Heart Hospital of Austin, Austin
Baylor Saint Luke's (The Texas Heart Institute), Houston
Houston Methodist Hospital, Houston
University of Texas Health Science Center at Houston, Houston
Methodist Hospital, San Antonio
VermontUniversity of Vermont Medical Center, Burlington
VirginiaUniversity of Virginia Medical Center, Charlottesville
Inova Fairfax Hospital, Falls Church
Sentara Norfolk General Hospital, Norfolk
WashingtonProvidence Heart Institute (Providence Sacred Heart), Spokane
WisconsinAurora St. Lukes Medical Center, Milwaukee
Froedtert Hospital, Milwaukee

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.