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Train Your Brain Fitness SC: An Exercise Intervention for People With Cognitive Impairments

Who can join

Ages 18 and older · All sexes

Inclusion criteria:

* adult (age \>18)
* medical diagnosis of mild-moderate cognitive impairment
* medical clearance by referring provider for exercise
* able to follow 2-step commands

Exclusion criteria:

* significant pain with movement (\>5/10)
* severe balance impairments or lack of independence on and off exercise equipment (by physical therapist judgment at Intake)

About the study

The goal of this clinical trial is to test a twice a week, moderate intensity exercise and coaching program (an in-person group and a distance group) for adults with mild-moderate cognitive impairments living in South Carolina. The main questions it aims to answer are:

1. Is the program practical to conduct, and it is acceptable and enjoyable? The hypothesis is that it will be possible to recruit participants, obtain the desired dosage of moderate intensity fitness and strength training twice a week for both groups. 2. Are their changes at 3, 6, 9 and 12 months in endurance, mobility, cognitive function and perception of cognitive function? The hypotheses are that endurance, strength and mobility will improve and cognitive measures will not decline (remain the same or improve) for both groups.

What is being tested

• Supervised Exercise and Behavior Modification Support (behavioral)
• Monitored Exercise and Behavioral Modification Support (behavioral)

Sponsor: University of South Carolina · Participants: 50 · Started: Mar 13, 2026

Contact the study team

• Elizabeth Regan, PhD · Phone: 7046092409
• Amberly Osteen · Phone: (803) 216-3896

Official record on ClinicalTrials.gov — NCT06799429

Locations in the U.S.

Conditions

• Mild Cognitive Impairment

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.