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A Multilevel Intervention to Increase Colorectal Cancer Screening Tests in Patients With Abnormal Fecal Immunochemical Test Results, PROACT Trial
PROACT: Promoting Follow-Up of Abnormal Colorectal Cancer Screening Tests Through Multilevel Interventions
Who can join
Ages 45 to 75 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * PATIENTS: Age \>= 45 years old and =\< 75 years old * PATIENTS: Receives care at an Harborview Medical Center (HMC) or University of Washington-Kent-Des Moines (UW-KDM) or University of Washington- Federal Way (UW-Federal Way) primary care clinic * PATIENTS: \>= 1 month from documented abnormal FIT result * PATIENTS: Has not received a colonoscopy between the abnormal FIT and enrollment * CLINIC STAFF: HMC, UW-Federal Way, or UW-KDM physician or staff member who provides primary care or gastroenterology care * CLINIC STAFF: Staff in the Fred Hutchinson (Fred Hutch)/UW Medicine Population Health Program that provide colorectal cancer screening and navigation
About the study
This clinical trial studies whether an intervention that addresses two or more levels of care (multilevel intervention) increases follow-up of abnormal, non-invasive, colorectal cancer (CRC) screening test results. The fecal immunochemical test (FIT) is a non-invasive, stool-based, CRC screening test. FITs are relatively inexpensive and can be completed at home, for these reasons, it is a preferred method of CRC screening in healthcare settings that care for under-resourced patients or have limited colonoscopy access. For FIT-based CRC screening to be effective, abnormal results must be followed by a colonoscopy, however many patients fail to complete this recommended follow-up test. The multilevel intervention addresses barriers to follow-up colonoscopy at the patient and health system levels of care through a CRC screening patient navigator, an educational video, and transportation assistance. The navigator provides patient support and assistance with colonoscopy scheduling. The educational video addresses identified patient fears around colonoscopies. Transportation assistance is offered after the colonoscopy through a rideshare program to address transportation barriers. Therefore, this multilevel intervention may increase follow-up colonoscopy completion in patients with abnormal FIT results.
What is being tested
- Best Practice (other)
- Educational Intervention (other)
- Electronic Health Record Review (other)
- Interview (other)
- Supportive Care (other)
- Survey Administration (other)
Sponsor: Fred Hutchinson Cancer Center · Participants: 682 · Started: Dec 16, 2025
Contact the study team
- Rachel B. Issaka, MD, MAS · Phone: 206-667-1447
Official record on ClinicalTrials.gov — NCT06822530
Locations in the U.S.
| Washington | Fred Hutch/University of Washington Cancer Consortium, Seattle |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.