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Feasibility of Resting Intervals During Exercise Programs for Individuals With Knee Osteoarthritis

Recruiting

Mechanical and Molecular Determinants of Cartilage Response to Exercise

Who can join

Ages 45 to 79 · All sexes

Full eligibility criteria
Inclusion Criteria:

* Age between 45 and 79 yo.
* Clinical diagnosis of primary, early to moderate stage knee osteoarthritis.
* BMI range \< 35 kg/m2.
* Sedentary lifestyle
* Knee joint is the most painful joint in the body.
* Ability to speak and understand English.
* Willingness to comply with all study procedures and be available for the duration of the study.

Exclusion Criteria:

* Non-OA disease of the knee.
* Advanced knee osteoarthritis
* Knee injection in the past 3 months.
* Major knee trauma/surgery in the past 5 years or previous knee surgery with hardware limiting cartilage assessment..
* Participate in regular exercise or physical activity .
* Participation in an intervention study for knee OA.
* Currently using a cane, walker or crutches to walk.
* History of cardiovascular disease or hypertension not controlled by medication.
* Two or more unexplained falls in the past year.
* Inflammatory, autoimmune disorders, neurological, systemic, muscular, or connective tissue conditions that affect walking or ability to exercise.
* Contraindication to MRI.
* Medical condition or characteristic of the participant that could place the individual at increased risk or preclude s/he from complying with study procedures.
* Pregnant female.
* Acute or terminal illness.

About the study

This pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis. One group receives the exercise program administered as usual, and the other group received the exercise program with resting intervals.

What is being tested

Sponsor: University of Pittsburgh · Participants: 20 · Started: Dec 4, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT06857123

Locations in the U.S.

PennsylvaniaUniversity of Pittsburgh, Pittsburgh

Conditions

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.