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Osteoarthritis clinical trials recruiting in the U.S.

68 studies for Osteoarthritis are recruiting participants at sites across the United States.

Osteoarthritis is the most common form of arthritis. It usually affects your hands, knees, hips, or spine. Learn about treatment and management.

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Recently updated studies

A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07919678

Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 5, 2026 · NCT07339111

Preoperative Music Intervention for Anxiety in Hip and Knee Arthroplasty

Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07845695

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07353931

EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))

Recruiting
Ages 21 and older · All sexes · Updated Nov 4, 2026 · NCT06631638

Oral Nutritional Optimization in Total Joint Arthroplasty

Recruiting
Ages 55 and older · All sexes · Updated Oct 30, 2026 · NCT04210284

Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis

RecruitingPhase 2
Ages 40 to 80 · All sexes · Updated Oct 30, 2026 · NCT06859164

Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy

Recruiting
Ages 18 to 85 · All sexes · Updated Oct 30, 2026 · NCT06965452

Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA

RecruitingPhase 4
Ages 18 to 89 · All sexes · Updated Oct 28, 2026 · NCT07430085

SMR Stemless Reverse vs SMR Reverse Shoulder System

Recruiting
Ages 22 and older · All sexes · Updated Oct 28, 2026 · NCT04697004

Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain

Recruiting
Ages 50 to 64 · All sexes · Updated Oct 27, 2026 · NCT07674901

A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients (MOTION-P)

RecruitingPhase 3
Ages 40 to 80 · All sexes · Updated Oct 16, 2026 · NCT07219771

Z1 Hip System: Post-Market Clinical Follow Up Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT07104279

Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cells for OA

RecruitingPhase 1
All ages · All sexes · Updated Oct 16, 2026 · NCT05147675

Intra-Articular Allocetra in Patients With Primary Knee Osteoarthritis

RecruitingPhase 2
Ages 64 and older · All sexes · Updated Oct 13, 2026 · NCT07580716

MaioRegen Prime Study for the Treatment of Deep Osteochondral Lesion of the Knee

Recruiting
Ages 18 to 60 · All sexes · Updated Oct 6, 2026 · NCT07332182

Expanding Exercise Programming for Veterans Through Telehealth

Recruiting
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05666167

Post-op Prednisone and Glucose Monitoring in TKA

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07630896

Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal

RecruitingHealthy volunteers welcome
Ages 18 to 85 · All sexes · Updated Sep 30, 2026 · NCT07673328

Low Dose Radiotherapy for Osteoarthritis

Recruiting
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07715188

ARVIS TKA vs Conventional TKA

Recruiting
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06663384

Ketorolac in Upper Extremity Tendinopathy and Arthropathy

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT05292339

Clinical Orthopaedic Data Bank (Acute and Chronic)

RecruitingObservational study
All ages · All sexes · Updated Sep 3, 2026 · NCT00411060

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.