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Osteoarthritis clinical trials recruiting in the U.S.

65 studies for Osteoarthritis are recruiting participants at sites across the United States.

Osteoarthritis is the most common form of arthritis. It usually affects your hands, knees, hips, or spine. Learn about treatment and management.

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Recently updated studies

Preoperative Music Intervention for Anxiety in Hip and Knee Arthroplasty

Recruiting
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07845695

EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))

Recruiting
Ages 21 and older · All sexes · Updated Sep 25, 2026 · NCT06631638

Post-op Prednisone and Glucose Monitoring in TKA

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07630896

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07153471

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07353931

Low Dose Radiotherapy for Osteoarthritis

Recruiting
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07715188

Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Sep 17, 2026 · NCT07339111

ARVIS TKA vs Conventional TKA

Recruiting
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06663384

Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain

Recruiting
Ages 50 to 64 · All sexes · Updated Sep 8, 2026 · NCT07674901

Clinical Orthopaedic Data Bank (Acute and Chronic)

RecruitingObservational study
All ages · All sexes · Updated Sep 3, 2026 · NCT00411060

Ketorolac in Upper Extremity Tendinopathy and Arthropathy

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT05292339

Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy

Recruiting
Ages 18 to 64 · All sexes · Updated Sep 2, 2026 · NCT06893302

Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy

Recruiting
Ages 18 to 85 · All sexes · Updated Sep 1, 2026 · NCT06965452

Z1 Hip System: Post-Market Clinical Follow Up Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07104279

Intra-Articular Allocetra in Patients With Primary Knee Osteoarthritis

RecruitingPhase 2
Ages 64 and older · All sexes · Updated Aug 26, 2026 · NCT07580716

A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee

RecruitingPhase 2
Ages 45 to 80 · All sexes · Updated Aug 25, 2026 · NCT06884865

A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System

RecruitingObservational study
Ages 21 and older · All sexes · Updated Aug 24, 2026 · NCT07118501

Novel Extended-Release Bupivacaine Polymer for Sustained Pain Relief Following Total Knee Arthroplasty

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT07775248

Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT06603662

Genicular Artery Embolization for Knee Osteoarthritis

Recruiting
Ages 40 to 80 · All sexes · Updated Jul 14, 2026 · NCT07537153

Clinical Outcomes Study of the Nexel Total Elbow

Recruiting
Ages 18 and older · All sexes · Updated Jul 9, 2026 · NCT02469662

Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal

RecruitingHealthy volunteers welcome
Ages 18 to 85 · All sexes · Updated Jun 29, 2026 · NCT07673328

Registry of Outcomes of Dezawa MuseCells®

RecruitingObservational study
Up to age 89 · All sexes · Updated Jun 12, 2026 · NCT07645989

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.