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Osteoarthritis clinical trials recruiting in the U.S.
65 studies for Osteoarthritis are recruiting participants at sites across the United States.
Osteoarthritis is the most common form of arthritis. It usually affects your hands, knees, hips, or spine. Learn about treatment and management.
Cities with the most studies
- Chicago, IL9 studies
- New York City, NY8 studies
- Gainesville, FL4 studies
- Atlanta, GA4 studies
- Houston, TX4 studies
- Charlotte, NC4 studies
- Philadelphia, PA4 studies
- Salt Lake City, UT4 studies
- Tampa, FL3 studies
- New Orleans, LA3 studies
- Orlando, FL3 studies
- Troy, MI3 studies
- Dallas, TX3 studies
- Phoenix, AZ3 studies
- Huntington Beach, CA3 studies
- Aurora, CO3 studies
- Birmingham, AL3 studies
- El Cajon, CA3 studies
By state
- Alabama4 studies
- Arizona6 studies
- California8 studies
- Colorado8 studies
- Florida13 studies
- Georgia4 studies
- Illinois10 studies
- Indiana3 studies
- Kentucky4 studies
- Louisiana4 studies
- Massachusetts6 studies
- Michigan5 studies
- New York12 studies
- North Carolina9 studies
- Ohio5 studies
- Pennsylvania13 studies
- South Carolina4 studies
- Tennessee5 studies
- Texas5 studies
- Utah5 studies
- Virginia4 studies
- Washington3 studies
Recently updated studies
Preoperative Music Intervention for Anxiety in Hip and Knee Arthroplasty
Recruiting
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07845695EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))
Recruiting
Ages 21 and older · All sexes · Updated Sep 25, 2026 · NCT06631638Post-op Prednisone and Glucose Monitoring in TKA
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07630896A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07153471Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07353931Low Dose Radiotherapy for Osteoarthritis
Recruiting
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07715188Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Sep 17, 2026 · NCT07339111ARVIS TKA vs Conventional TKA
Recruiting
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06663384Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain
Recruiting
Ages 50 to 64 · All sexes · Updated Sep 8, 2026 · NCT07674901Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
Recruiting
Ages 40 and older · All sexes · Updated Sep 4, 2026 · NCT07804446Clinical Orthopaedic Data Bank (Acute and Chronic)
RecruitingObservational study
All ages · All sexes · Updated Sep 3, 2026 · NCT00411060Ketorolac in Upper Extremity Tendinopathy and Arthropathy
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT05292339Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy
Recruiting
Ages 18 to 64 · All sexes · Updated Sep 2, 2026 · NCT06893302Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy
Recruiting
Ages 18 to 85 · All sexes · Updated Sep 1, 2026 · NCT06965452Z1 Hip System: Post-Market Clinical Follow Up Study
RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07104279Intra-Articular Allocetra in Patients With Primary Knee Osteoarthritis
RecruitingPhase 2
Ages 64 and older · All sexes · Updated Aug 26, 2026 · NCT07580716A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee
RecruitingPhase 2
Ages 45 to 80 · All sexes · Updated Aug 25, 2026 · NCT06884865A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System
RecruitingObservational study
Ages 21 and older · All sexes · Updated Aug 24, 2026 · NCT07118501Novel Extended-Release Bupivacaine Polymer for Sustained Pain Relief Following Total Knee Arthroplasty
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT07775248Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT06603662A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)
RecruitingObservational study
Ages 18 to 80 · All sexes · Updated Aug 6, 2026 · NCT07199738Genicular Artery Embolization for Knee Osteoarthritis
Recruiting
Ages 40 to 80 · All sexes · Updated Jul 14, 2026 · NCT07537153Clinical Outcomes Study of the Nexel Total Elbow
Recruiting
Ages 18 and older · All sexes · Updated Jul 9, 2026 · NCT02469662Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal
RecruitingHealthy volunteers welcome
Ages 18 to 85 · All sexes · Updated Jun 29, 2026 · NCT07673328Registry of Outcomes of Dezawa MuseCells®
RecruitingObservational study
Up to age 89 · All sexes · Updated Jun 12, 2026 · NCT07645989From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.