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Safety of Short-course of NSAIDs in Pediatric Patients With CKD

Safety of Short-term NSAID Use in the Postoperative Setting in Pediatric Patients With Chronic Kidney Disease

Who can join

18 Months – 25 Years · All sexes

Inclusion Criteria:

* Patients over 18 months of age
* diagnosis of CKD stages 2-3a, confirmed by CKiD U25 eGFR calculator based on cystatin C laboratory testing within 6 months of surgery
* Patient is scheduled to undergo a urologic surgery requiring admission or overnight stay in the hospital

Exclusion Criteria:

* Diagnosis of CKD stage 1 or 4-5
* Past medical history of renal transplant
* Past medical history of nasal polyp
* Procedure for oncologic indications or on chemotherapy
* Pregnant patient
* True allergy to NSAIDs

About the study

The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney disease (CKD). The investigators hypothesize that there is no increased risk. This is currently in the process of developing multi institution collaboration within a Pediatric Urology population, intended to inform future work in a larger patient population.

What is being tested

• NSAIDs (drug)
• Placebo (drug)

Sponsor: University of Colorado, Denver · Participants: 164 · Started: Jul 22, 2025

Contact the study team

• Kyle Rove, MD · Phone: 7209758206
• Jennifer Pyrzanowski, MSPH · Phone: 413-329-5321

Official record on ClinicalTrials.gov — NCT06860711

Locations in the U.S.

Conditions

• Chronic Kidney Disease

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.