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Well-being in IBS: Strengths and Happiness (WISH) 2.0

Recruiting

The WISH Intervention for IBS: Feasibility, Preliminary Effects, and Candidate Gut-Brain Mechanisms

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* IBS Diagnosis: Adult patients with an IBS diagnosis meeting standardized Rome IV diagnostic criteria.
* Language and communication: English fluency and access to a phone.

Exclusion Criteria:

* Presence of inflammatory bowel disease or other structural/biochemical primary gastrointestinal illness that better explains IBS-like symptoms: As reported by the patient, their physician, and/or documented in the medical record.
* Severe psychiatric illness: Current manic episode, psychosis, or active substance use disorder diagnosed via the Mini International Neuropsychiatric Interview (MINI) or Diagnostic Interview for Anxiety, Mood, and OCD and Related Neuropsychiatric Disorders (DIAMOND).
* Cognitive impairment: Assessed using a six-item cognitive screen developed for research.
* Presence of atrial fibrillation or a cardiac pacemaker, or daily use of beta blocking medication: As reported by the patient and/or documented in the medical record.
* Plans to start or participate in another new behavioral health intervention or psychotherapy during the study period.

About the study

The purpose of this study is to examine the feasibility, acceptability, preliminary effects, and candidate gut-brain mechanisms of an optimized positive psychology (PP) intervention for patients with irritable bowel syndrome (IBS), entitled "WISH," compared to an educational control intervention.

What is being tested

Sponsor: Massachusetts General Hospital · Participants: 50 · Started: Oct 30, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT06866106

Locations in the U.S.

MassachusettsMassachusetts General Hospital, Boston

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.