Home › Paraproteinemias › NCT06870760

Pre-malignant States to Hematologic Malignancies in Firefighters

Who can join

Ages 40 to 49 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

1. Written informed consent and HIPAA authorization for release of personal health information.
2. Age ≥ 40-49 years at the time of consent (self-reported)
3. Ability of the participant to understand and comply with study procedures for the entire length of the study
4. Currently employed by Charlotte Fire Department (CFD) with at least 5 years on-the -job experience (self-reported)

Exclusion Criteria:

Anyone with a current diagnosis of a hematologic malignancy will be excluded.

About the study

The purpose of the study is to evaluate if firefighter exposure to hazardous compounds will increase the incidence of premalignant hematological states which subsequently increases the risk of the development of hematologic malignancies, and potentially other pathophysiological consequences.

What is being tested

• Monoclonal Gammopathy (other)
• Complete Blood Count with differential (CBC w/ diff) (other)
• Clonal hematopoiesis (CHIP) (other)

Sponsor: Wake Forest University Health Sciences · Participants: 300 · Started: Jun 23, 2026

Contact the study team

• Megan Lattanze · Phone: 980-442-4239

Official record on ClinicalTrials.gov — NCT06870760

Locations in the U.S.

Conditions

• Paraproteinemias
• Non-Hodgkin Lymphoma
• Leukemia
• Multiple Myeloma
• Plasma Cell Cancer

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.