Home › Drug Use and Addiction › NCT06880705

The Trans-Led Care Study

A Gender-Affirming Stigma Intervention to Improve Substance Misuse and HIV Risk Among Transgender Women

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

Eligible transgender adults must:

1. be 18 years of age or older;
2. speak primarily English;
3. live in the U.S.;
4. have a gender identity different from their assumed gender, or sex assigned, at birth;
5. identify as a person of transgender experience;
6. endorse having experienced two or more problem(s) related to alcohol or other drug use within the past 12 months.

About the study

This study is testing a new mutual-help group called "the TLC program" for transgender adults who use substances or are recently in recovery. The TLC Program is based on Acceptance and Commitment Therapy or "ACT" which is a type of mental health counseling that focuses on using mindfulness skills to connect a person to their values and improve their mental health. The TLC Program was developed by transgender and gender diverse community members, mental health providers, and researchers.

What is being tested

• The TLC Program (behavioral)

Sponsor: Illinois Institute of Technology · Participants: 124 · Started: Apr 14, 2026

Contact the study team

• Arryn Guy, PhD · Phone: 312-567-6467

Official record on ClinicalTrials.gov — NCT06880705

Locations in the U.S.

Conditions

• Drug Use and Addiction
• HIV
• Social Stigma

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.