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EEG-based Personalized Transcranial Magnetic Stimulation (eTMS) to Treat Post-Traumatic Stress Disorder
A Randomized Controlled Trial of Electroencephalogram (EEG) Personalized Transcranial Magnetic Stimulation (eTMS) for Post-Traumatic Stress Disorder
Who can join
Ages 22 to 65 · All sexes
Full eligibility criteria
Inclusion Criteria: * Willing and able to consent to participate in the study via signed Informed Consent * Age 22 - 65 years * Diagnosis of PTSD according to DSM-5 criteria via the Clinician-Administered PTSD Scale (CAPS). * Onset of symptoms meeting the DSM-5 criteria for PTSD symptoms persisting for a minimum of 6 months prior to the Screening Visit * Veterans Administration PCL-5 cut point score of 31 or above * Positive identification as either a Veteran, or First Responder (e.g., emergency medical service provider, firefighter, or any other emergency response personnel) Exclusion Criteria: * Uncontrolled medical, psychological or neurological condition * Pregnant, or female unwilling to use effective birth control during the course of the trial * Metal objects in the head * Past exposure to metal fragments, permanent piercings, and/or other possible metal sources in the head and neck * Current participation in any interventional research protocol * History of any type of Electroconvulsive Therapy (ECT) or repetitive Transcranial Magnetic Stimulation (rTMS) * History of stroke or intracranial lesion or increased intracranial pressure * History of epilepsy of seizure * Family history of epilepsy or seizure in 1st degree relative * An elevated risk of suicide or violence to others
About the study
This is a randomized, sham controlled study of the Electroencephalogram (EEG) based Transcranial Magnetic Stimulation (eTMS) treatment for Post-Traumatic Stress Disorder (PTSD). The recruitment goal is 110 participants who are United States Military veterans or first responders (e.g., firefighters, police, paramedics, etc.). The Study includes an EEG recording in order to determine the optimal treatment parameters for the eTMS system, followed by 15 in-office visits that take place over 21-28 total days. Two eTMS treatment sessions are administered during each office visit.
What is being tested
- EEG-based personalized TMS (device)
- Sham Comparator (device)
Sponsor: Wave Neuroscience · Participants: 110 · Started: Feb 12, 2025
Contact the study team
- Matthew Sherwood, PhD · Phone: 937-775-2342
- Walter Mysiw, MD · Phone: 614-293-3433
Official record on ClinicalTrials.gov — NCT06892028
Locations in the U.S.
| Ohio | Wright State University, Dayton D2 Human Performance Center, Pickerington |
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.