Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines
RecruitingPhase 3
Evaluating the Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines in the Emergency Department
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Age ≥ 18 years or older * Able to provide informed consent * English speaking * Primary diagnosis of migraine. Patient with a previous diagnosis of migraine, who experience headaches with typical migraine features (e.g at least 2-3 of the following: recurrent, unilateral, pounding or throbbing in nature, associated with nausea), AND with a clinical exclusion of migraine mimics Exclusion Criteria: * Pregnancy defined as a positive urine HCG * Allergy or sensitivity to study drug * Stated history of renal insufficiency * Documented history of myasthenia gravis * Consumption of study drug within 48 hours prior to enrollment * Previously enrolled in this trial during a different patient encounter
About the study
The purpose of this research study is to find out if using magnesium in addition to prochlorperazine will help reduce your migraine pain.
What is being tested
- Magnesium (drug)
- Placebo (drug)
Sponsor: Wake Forest University Health Sciences · Participants: 100 · Started: Dec 16, 2025
Contact the study team
- Ryan McKillip, MD · Phone: 708-684-6230
- Marc McDowell, PharmD · Phone: 708-684-1078
Official record on ClinicalTrials.gov — NCT06904287
Locations in the U.S.
| Illinois | Advocate Christ Medical Center Emergency Department, Oak Lawn |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.