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Migraine clinical trials recruiting in the U.S.
57 studies for Migraine are recruiting participants at sites across the United States.
Migraines are pulsing or throbbing headaches in one area of the head. Learn about other symptoms, what triggers migraines, and how to treat them.
Cities with the most studies
- Cincinnati, OH11 studies
- Miami, FL8 studies
- Austin, TX8 studies
- Concord, CA8 studies
- Philadelphia, PA8 studies
- Washington, DC7 studies
- Omaha, NE7 studies
- Amherst, NY7 studies
- Houston, TX7 studies
- Aurora, CO6 studies
- Tampa, FL6 studies
- San Diego, CA6 studies
- Charlotte, NC6 studies
- New York City, NY6 studies
- Salt Lake City, UT6 studies
- Stamford, CT6 studies
- Portland, OR6 studies
- Orlando, FL6 studies
- Atlanta, GA6 studies
- Milwaukee, WI5 studies
- Boston, MA5 studies
- Norfolk, VA5 studies
- Ann Arbor, MI5 studies
- Dallas, TX5 studies
- Fresno, CA5 studies
- Phoenix, AZ5 studies
- Nashville, TN5 studies
- Morgantown, WV5 studies
- Warwick, RI4 studies
- Los Angeles, CA4 studies
- St. Louis, MO4 studies
- Baltimore, MD4 studies
- Pomona, CA4 studies
- Naperville, IL4 studies
- Anaheim, CA4 studies
- Long Beach, CA4 studies
- East Norwalk, CT4 studies
- Chicago, IL4 studies
- Jackson, MS4 studies
- Columbus, OH4 studies
By state
- Alabama5 studies
- Arizona10 studies
- Arkansas3 studies
- California18 studies
- Colorado7 studies
- Connecticut9 studies
- District of Columbia5 studies
- Florida12 studies
- Georgia9 studies
- Illinois6 studies
- Indiana3 studies
- Iowa5 studies
- Kansas5 studies
- Kentucky4 studies
- Louisiana3 studies
- Maryland7 studies
- Massachusetts8 studies
- Michigan6 studies
- Minnesota7 studies
- Mississippi4 studies
- Missouri6 studies
- Nebraska8 studies
- Nevada3 studies
- New Jersey7 studies
- New York15 studies
- North Carolina12 studies
- Ohio12 studies
- Oregon6 studies
- Pennsylvania8 studies
- Rhode Island5 studies
- South Carolina4 studies
- Tennessee7 studies
- Texas13 studies
- Utah7 studies
- Virginia6 studies
- Washington5 studies
- West Virginia10 studies
- Wisconsin8 studies
Recently updated studies
Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 29, 2026 ยท NCT07361549A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of Migraine
RecruitingPhase 1
Ages 6 to 11 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT06995729Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects
RecruitingPhase 3
Ages 6 to 17 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT05156398MMA Embolization for Refractory Chronic Migraine
Recruiting
Ages 18 to 65 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT06735833The Effect of Remote Electrical Neuromodulation (REN) on Conditioned Pain Modulation (CPM) in Migraine and Fibromyalgia
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07841509Randomized Study in Children and Adolescents With Migraine: Acute Treatment
RecruitingPhase 3
Ages 6 to 17 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT04649242A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache
RecruitingPhase 4
Ages 18 to 65 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT06473597Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine
RecruitingPhase 3
Ages 6 to 17 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT04743141EMBRACE-OBS: Single-Site Observational Registry of Patient-Reported Outcomes Following MMA Embolization for Migraine
RecruitingObservational study
Ages 18 to 64 ยท All sexes ยท Updated Sep 23, 2026 ยท NCT07652034A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years
RecruitingPhase 3
Ages 12 to 17 ยท All sexes ยท Updated Sep 22, 2026 ยท NCT06810505Puberty, Testosterone, and Brain Development
RecruitingObservational study
Ages 12 to 20 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT06670053Responding With Evidence and Access for Childhood Headaches
Recruiting
Ages 10 to 17 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT05889624Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive Medications
RecruitingPhase 4
Ages 18 and older ยท All sexes ยท Updated Sep 17, 2026 ยท NCT06401642Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study
RecruitingPhase 4
Ages 18 to 70 ยท All sexes ยท Updated Sep 16, 2026 ยท NCT06972056Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)
RecruitingPhase 3
Ages 6 to 17 ยท All sexes ยท Updated Sep 14, 2026 ยท NCT05125302Objectively Diagnose and Monitor Treatment of Light Sensitivity
RecruitingHealthy volunteers welcome
Ages 18 to 80 ยท All sexes ยท Updated Sep 8, 2026 ยท NCT03694626Bilateral Embolization of the Middle Meningeal Arteries for Refractory Chronic Migraine
Recruiting
Ages 18 to 80 ยท All sexes ยท Updated Sep 3, 2026 ยท NCT07223008Study of EVO756 in Adults With Migraine
RecruitingPhase 2
Ages 18 to 64 ยท All sexes ยท Updated Sep 3, 2026 ยท NCT07616128Study Evaluating the Efficacy, Safety, and Tolerability of ASY202 (Dihydroergotamine Mesylate [DHE] Inhalation Powder Delivered Via a Multidose Dry Powder Inhaler) for the Acute Treatment of Migraine in Adult Patients
RecruitingPhase 2
Ages 18 to 65 ยท All sexes ยท Updated Sep 2, 2026 ยท NCT07646613A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant Migraine
Recruiting
Ages 22 to 84 ยท All sexes ยท Updated Aug 28, 2026 ยท NCT07719608A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Aug 20, 2026 ยท NCT07645924NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 70 ยท All sexes ยท Updated Aug 13, 2026 ยท NCT05669703Emgality for Migraine in Breastmilk
RecruitingObservational study
Ages 18 to 45 ยท Women ยท Updated Aug 11, 2026 ยท NCT06085144Headache Ear Auditory Dizziness Sinus (HEADS) Registry
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Aug 10, 2026 ยท NCT07754266Mechanistic Studies of Psilocybin in Headache Disorders
RecruitingEarly phase 1Healthy volunteers welcome
Ages 21 to 70 ยท All sexes ยท Updated Jul 13, 2026 ยท NCT06464367From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.