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Migraine clinical trials recruiting in the U.S.

60 studies for Migraine are recruiting participants at sites across the United States.

Migraines are pulsing or throbbing headaches in one area of the head. Learn about other symptoms, what triggers migraines, and how to treat them.

Cities with the most studies

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Recently updated studies

Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

RecruitingPhase 4
Ages 18 to 70 ยท All sexes ยท Updated Nov 13, 2026 ยท NCT06972056

Study of EVO756 in Adults With Migraine

RecruitingPhase 2
Ages 18 to 64 ยท All sexes ยท Updated Nov 13, 2026 ยท NCT07616128

A Study to Assess the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine

RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT07816367

Headache Education and Awareness vs. Daily Mindfulness Strategies - Understanding Pain

Recruiting
Ages 12 to 17 ยท All sexes ยท Updated Nov 5, 2026 ยท NCT07513662

Marine Lipids Ease Painful TMD

Recruiting
Ages 18 and older ยท All sexes ยท Updated Nov 5, 2026 ยท NCT07437313

A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine

RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Nov 2, 2026 ยท NCT07645924

Dietary Intervention for Migraine Relief

Recruiting
Ages 18 to 75 ยท All sexes ยท Updated Oct 30, 2026 ยท NCT07360405

Observational Study to Assess Maternal, Fetal and Infant Outcomes Following Exposure to Rimegepant

RecruitingObservational study
Ages 0 and older ยท Women ยท Updated Oct 29, 2026 ยท NCT05046613

A Prospective, Open-Label Study Evaluating the Effectiveness of Gepants for Acute Treatment of Migraine in the Emergency Department

RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Oct 27, 2026 ยท NCT07667621

Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine

RecruitingPhase 3
Ages 6 to 17 ยท All sexes ยท Updated Oct 27, 2026 ยท NCT04743141

Randomized Study in Children and Adolescents With Migraine: Acute Treatment

RecruitingPhase 3
Ages 6 to 17 ยท All sexes ยท Updated Oct 27, 2026 ยท NCT04649242

Overlapping Pain Trajectory Study

RecruitingObservational studyHealthy volunteers welcome
Ages 10 to 19 ยท All sexes ยท Updated Oct 20, 2026 ยท NCT05752396

Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects

RecruitingPhase 3
Ages 6 to 17 ยท All sexes ยท Updated Oct 14, 2026 ยท NCT05156398

A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine

RecruitingPhase 3
Ages 6 to 17 ยท All sexes ยท Updated Oct 14, 2026 ยท NCT05164172

RELAXaHEAD for Headache Patients (Phase III)

Recruiting
Ages 16 to 80 ยท All sexes ยท Updated Oct 8, 2026 ยท NCT06077838

Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy

RecruitingPhase 3
Ages 18 to 55 ยท All sexes ยท Updated Oct 8, 2026 ยท NCT07629635

NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 70 ยท All sexes ยท Updated Oct 7, 2026 ยท NCT05669703

Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Oct 1, 2026 ยท NCT07361549

A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of Migraine

RecruitingPhase 1
Ages 6 to 11 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT06995729

The Effect of Remote Electrical Neuromodulation (REN) on Conditioned Pain Modulation (CPM) in Migraine and Fibromyalgia

Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07841509

A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache

RecruitingPhase 4
Ages 18 to 65 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT06473597

EMBRACE-OBS: Single-Site Observational Registry of Patient-Reported Outcomes Following MMA Embolization for Migraine

RecruitingObservational study
Ages 18 to 64 ยท All sexes ยท Updated Sep 23, 2026 ยท NCT07652034

Puberty, Testosterone, and Brain Development

RecruitingObservational study
Ages 12 to 20 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT06670053

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.