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Migraine clinical trials recruiting in the U.S.
60 studies for Migraine are recruiting participants at sites across the United States.
Migraines are pulsing or throbbing headaches in one area of the head. Learn about other symptoms, what triggers migraines, and how to treat them.
Cities with the most studies
- Cincinnati, OH12 studies
- Omaha, NE9 studies
- Austin, TX9 studies
- Aurora, CO8 studies
- Miami, FL8 studies
- Stamford, CT8 studies
- Atlanta, GA8 studies
- Washington, DC8 studies
- Phoenix, AZ7 studies
- Philadelphia, PA7 studies
- Tampa, FL7 studies
- San Diego, CA7 studies
- Houston, TX7 studies
- Orlando, FL7 studies
- Dallas, TX7 studies
- Amherst, NY7 studies
- Concord, CA7 studies
- Salt Lake City, UT7 studies
- Nashville, TN6 studies
- Charlotte, NC6 studies
- Portland, OR6 studies
- New York City, NY6 studies
- Columbus, OH5 studies
- Fresno, CA5 studies
- Ann Arbor, MI5 studies
- Norfolk, VA5 studies
- Long Beach, CA5 studies
- Morgantown, WV4 studies
- Winston-Salem, NC4 studies
- Milwaukee, WI4 studies
- St. Louis, MO4 studies
- Pomona, CA4 studies
- Raleigh, NC4 studies
- Boston, MA4 studies
- Baltimore, MD4 studies
- Naperville, IL4 studies
- El Paso, TX4 studies
- East Norwalk, CT4 studies
- Anaheim, CA4 studies
- Chicago, IL4 studies
By state
- Alabama5 studies
- Arizona12 studies
- Arkansas4 studies
- California17 studies
- Colorado10 studies
- Connecticut10 studies
- District of Columbia6 studies
- Florida13 studies
- Georgia11 studies
- Idaho3 studies
- Illinois7 studies
- Indiana5 studies
- Iowa6 studies
- Kansas5 studies
- Kentucky4 studies
- Louisiana3 studies
- Maryland7 studies
- Massachusetts9 studies
- Michigan6 studies
- Minnesota7 studies
- Mississippi4 studies
- Missouri7 studies
- Nebraska10 studies
- Nevada4 studies
- New Jersey9 studies
- New York16 studies
- North Carolina15 studies
- Ohio14 studies
- Oregon6 studies
- Pennsylvania7 studies
- Rhode Island5 studies
- South Carolina4 studies
- Tennessee7 studies
- Texas14 studies
- Utah8 studies
- Virginia7 studies
- Washington5 studies
- West Virginia8 studies
- Wisconsin7 studies
Recently updated studies
Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study
RecruitingPhase 4
Ages 18 to 70 ยท All sexes ยท Updated Nov 13, 2026 ยท NCT06972056Study of EVO756 in Adults With Migraine
RecruitingPhase 2
Ages 18 to 64 ยท All sexes ยท Updated Nov 13, 2026 ยท NCT07616128A Study to Assess the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT07816367Headache Education and Awareness vs. Daily Mindfulness Strategies - Understanding Pain
Recruiting
Ages 12 to 17 ยท All sexes ยท Updated Nov 5, 2026 ยท NCT07513662Marine Lipids Ease Painful TMD
Recruiting
Ages 18 and older ยท All sexes ยท Updated Nov 5, 2026 ยท NCT07437313A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Nov 2, 2026 ยท NCT07645924Dietary Intervention for Migraine Relief
Recruiting
Ages 18 to 75 ยท All sexes ยท Updated Oct 30, 2026 ยท NCT07360405Observational Study to Assess Maternal, Fetal and Infant Outcomes Following Exposure to Rimegepant
RecruitingObservational study
Ages 0 and older ยท Women ยท Updated Oct 29, 2026 ยท NCT05046613A Prospective, Open-Label Study Evaluating the Effectiveness of Gepants for Acute Treatment of Migraine in the Emergency Department
RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Oct 27, 2026 ยท NCT07667621Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine
RecruitingPhase 3
Ages 6 to 17 ยท All sexes ยท Updated Oct 27, 2026 ยท NCT04743141Randomized Study in Children and Adolescents With Migraine: Acute Treatment
RecruitingPhase 3
Ages 6 to 17 ยท All sexes ยท Updated Oct 27, 2026 ยท NCT04649242Overlapping Pain Trajectory Study
RecruitingObservational studyHealthy volunteers welcome
Ages 10 to 19 ยท All sexes ยท Updated Oct 20, 2026 ยท NCT05752396Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects
RecruitingPhase 3
Ages 6 to 17 ยท All sexes ยท Updated Oct 14, 2026 ยท NCT05156398A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine
RecruitingPhase 3
Ages 6 to 17 ยท All sexes ยท Updated Oct 14, 2026 ยท NCT05164172A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years
RecruitingPhase 3
Ages 12 to 17 ยท All sexes ยท Updated Oct 9, 2026 ยท NCT06810505Study Evaluating the Efficacy, Safety, and Tolerability of ASY202 (Dihydroergotamine Mesylate [DHE] Inhalation Powder Delivered Via a Multidose Dry Powder Inhaler) for the Acute Treatment of Migraine in Adult Patients
RecruitingPhase 2
Ages 18 to 65 ยท All sexes ยท Updated Oct 9, 2026 ยท NCT07646613RELAXaHEAD for Headache Patients (Phase III)
Recruiting
Ages 16 to 80 ยท All sexes ยท Updated Oct 8, 2026 ยท NCT06077838Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy
RecruitingPhase 3
Ages 18 to 55 ยท All sexes ยท Updated Oct 8, 2026 ยท NCT07629635NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 70 ยท All sexes ยท Updated Oct 7, 2026 ยท NCT05669703Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Oct 1, 2026 ยท NCT07361549A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of Migraine
RecruitingPhase 1
Ages 6 to 11 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT06995729The Effect of Remote Electrical Neuromodulation (REN) on Conditioned Pain Modulation (CPM) in Migraine and Fibromyalgia
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07841509A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache
RecruitingPhase 4
Ages 18 to 65 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT06473597EMBRACE-OBS: Single-Site Observational Registry of Patient-Reported Outcomes Following MMA Embolization for Migraine
RecruitingObservational study
Ages 18 to 64 ยท All sexes ยท Updated Sep 23, 2026 ยท NCT07652034Puberty, Testosterone, and Brain Development
RecruitingObservational study
Ages 12 to 20 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT06670053From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.