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Type 1 Diabetes and Obstructive Sleep Apnea
Recruiting
Obstructive Sleep Apnea and Glycemic Dysregulation in Adults With Type 1 Diabetes
Who can join
Ages 18 to 50 · All sexes
Full eligibility criteria
Inclusion Criteria: * Age: 18 to 50 years old * Type 1 Diabetes on insulin pump therapy and using a CGM device with an GMI (glucose management indicator) between 5.5 and 8.5% with hemoglobin in the normal range at screening * OSA by home sleep apnea test Exclusion Criteria: * Regular and adherent CPAP use per clinical guidelines * Requiring oxygen or advanced positive airway pressure modalities during sleep * Having a 'fall-asleep' or 'near miss' accident in the past 6-months * Shift work * Severe hypoglycemia (≥1 episode in the past 3 months or diagnosis of hypoglycemic unawareness) * ≥1 trip to emergency room for poor glucose management in the past 6 months * Proliferative retinopathy * Fasting triglycerides \>400mg/dL, * Liver transaminases \>2 times upper limit of normal, * Renal transplantation or serum creatinine \>1.5 mg/dL * Anemia (hemoglobin \<13.0g/dL in men or \<11.6g/dL in women) * Acute coronary syndrome or stroke past 6 months * Severe hypertension (blood pressure\>180/105 mmHg) * Any other significant health condition: unstable angina, heart failure requiring hospitalization in the past 6 months, significant heart block or arrhythmias, NYHA Class\>2, pulmonary disease with dependence on oxygen or daily use of bronchodilators, active or chronic infection, thyroid disease and other endocrine disorders (e.g. Cushing syndrome, acromegaly) * Recent major surgery * Major psychiatric disorder * Subjects will also be excluded if taking medications that can confound metabolic assessments including systemic glucocorticoids, antipsychotics, thiazide diuretics, beta-blockers, daily use of aminophylline or theophylline, or use of any immunosuppressant. * Currently pregnant or trying to get pregnant or nursing * Smoking, alcohol or illegal drug abuse
About the study
The purpose of the study is to investigate the role of sleep apnea in glycemic dysregulation in adults with Type 1 diabetes.
What is being tested
- Continuous positive airway pressure (CPAP) (device)
Sponsor: University of Chicago · Participants: 40 · Started: Nov 10, 2025
Contact the study team
- Esra Tasali, MD · Phone: 7738342663
- Becky Tucker · Phone: 7737022348
Official record on ClinicalTrials.gov — NCT06915831
Locations in the U.S.
| Illinois | University of Chicago, Chicago |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.