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Heat thErapy And mobiLity in COVID-19 Survivors

Physical Rehabilitation of Long COVID by Heat Therapy

Who can join

Ages 50 to 90 · All sexes

Inclusion Criteria:

* Between the ages of 50 and 90 years
* Free from orthopedic limitations that would prohibit performing leg exercise
* BMI \< 40 kg/m2 and weigh \< 400lbs
* Previously contracted Covid-19 and have persistent symptoms such as a fatigue or decline in physical function, for at least 2 months following SARS-CoV-2 infection

Exclusion Criteria:

* Unable to give written informed consent
* Women who are pregnant, breastfeeding, or likely to become pregnant within the next 6 months
* Claustrophobia
* Orthopedic limitations that would prohibit them from walking
* Currently enrolled in an exercise-based or respiratory muscle rehabilitation program.

About the study

Post-acute sequelae of SARS-CoV-2 infection (PASC) is becoming a major risk factor for chronic diseases, with older adults and those with underlying health conditions at risk of developing persistent mobility limitations and disabilities. Although exercise intervention is a common strategy to restore functional capacity, it may not be feasible or enticing to many people with PASC. This clinical trial seeks to establish the tolerability and efficacy of at home lower-body heat therapy for improving functional capacity along with metabolic and vascular health in late-middle aged and older adults with PASC, also known as "long COVID".

What is being tested

• Heat therapy (behavioral)
• Sham Control (behavioral)
• Walking (behavioral)

Sponsor: University of Nebraska · Participants: 99 · Started: Jan 16, 2025

Contact the study team

• Gwenael Layec, PhD · Phone: 402-554-3779

Official record on ClinicalTrials.gov — NCT06928116

Locations in the U.S.

Conditions

• Post-COVID Conditions (Long COVID)
• Hyperthermia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.