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Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA)

Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA): Pregnancy Registry for Women With Chronic Conditions

Who can join

Ages 18 to 64 · Women · Healthy volunteers welcome

Inclusion Criteria:

* Pregnant or contemplating pregnancy
* Female, aged 18 to 64 years
* Diagnosis of one of the following conditions:
* Clinically Isolated Syndrome (CIS) or Multiple Sclerosis (MS), based on the 2010 McDonald Criteria
* Neuromyelitis Optica Spectrum Disorder (NMOSD)
* Inflammatory Bowel Disease (IBD)
* Rheumatoid Arthritis (RA)
* Myasthenia Gravis
* Lupus
* Other chronic neurological conditions
* Willing to provide biosamples and/or complete surveys at specified timepoints
* Women without a chronic condition who are pregnant or contemplating pregnancy (as part of the control group)

Exclusion Criteria:

\- Unwillingness to provide informed consent

About the study

PRISMA, is a pregnancy registry study, focused on comprehensively collecting information about pregnancy in women with chronic neurological conditions from across the United States and internationally.

Depending on their specific condition (MS, CIS, NMOSD, or other) and their specific treatment, participants will be asked to contribute to different aspects of the study. (1) The biosamples will be blood, breast milk, infant stool, maternal stool and vaginal swab samples, collected at specific time points. (2) The online surveys will be collected at specific time points. All study activities will be discussed with participants upon enrollment.

By collecting this information, the investigators hope to gain deeper insights into the relationship between pregnancy, the neurological condition, and maternal and infant health. For example, one of the sub-studies focuses on breast milk collection for women planning postpartum treatment with Ocrevus, Rituxan, Briumvi or Kesimpta.

This study is fully remote and all sample collection is optional, so participants can choose which types of samples they wish to provide. For blood draws, participants can schedule a home visit through ExamOne, making participation even more convenient.

The investigators aim to enroll women with chronic neurological conditions who are planning pregnancy, currently pregnant, or within one year postpartum.

Sponsor: University of California, San Francisco · Participants: 250 · Started: Mar 21, 2017

Contact the study team

• Min Ji Kim Kim, BA · Phone: 415-502-7209

Official record on ClinicalTrials.gov — NCT06940323

Locations in the U.S.

Conditions

• Multiple Sclerosis
• Myasthenia Gravis

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.