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Huntington's Disease Biobank: Advancing Remote Monitoring and Deep Phenotyping
HD Project: Neurodegenerative Disease Research Platform - Novel Remote Monitoring and Deep Phenotyping.
Who can join
All ages · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Individuals with a positive test for the HD expansion mutation. Exclusion Criteria: * Individuals with movement disorders with a negative test for the HD expansion mutation.
About the study
This observational study aims to identify novel biomarkers of disease onset and progression in Huntington's disease by integrating remote monitoring with fluid biomarkers. Using video-based computer vision and mobile app-based cognitive assessments combined with machine learning algorithms, we aim to develop markers that can be used by Huntington's disease patients at home.
Using machine learning to analyze videos of movement will capture the movements with an accuracy that will be as good as seeing an expert neurologist. These individualized markers can be followed over time to evaluate symptoms onset and change. The study will track disease progression and correlate these digital markers with changes in plasma and cerebrospinal fluid. The ultimate goal is to advance biomarker discovery and therapeutic development for Huntington's disease.
The study includes one in-person visit per year. A remote visit via Zoom or Facetime (15 min) every three months to record videos of movement. We can also share cutting-edge wristbands and a mobile phone app.
What is being tested
- computer vision, remote monitoring, blood, urine, wrist bands, mobile-app (diagnostic test)
Sponsor: Stanford University · Participants: 200 · Started: Jun 1, 2024
Contact the study team
- Minhtrang Chu, Study Coordinator · Phone: 650-250-3160
- Olivia Lu, Study Coordinator · Phone: 650-374-9286
Official record on ClinicalTrials.gov — NCT06941662
Locations in the U.S.
| California | Stanford University, Palo Alto |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.