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Stepped Care for Posttraumatic Stress Disorder Study

Adaptive Interventions to Improve Posttraumatic Stress Disorder (PTSD) Treatment Access, Engagement, and Effectiveness in Routine Care

Who can join

Ages 18 and older · All sexes

Inclusion criteria:

Assessed at pre-screening

* Boston Medical Center primary care patient
* At least 18 years of age
* Access to computer or mobile device
* Able to receive treatments in English or Spanish
* Able to read at 4th grade level

Assessed at baseline

* Endorsement of Criterion A trauma using the Life Events Checklist for the DSM-5 (LEC-5), assessed at baseline
* PTSD diagnosis, confirmed by the Clinician-Administered PTSD Scale for the DSM-5 (CAPS-5) assessed at baseline

  \- Concordance between CAPS-5 and PCL-5 at baseline
* Clinically appropriate for outpatient level of care
* Stable on psychotropic medication for \>4 weeks

Exclusion criteria:

Assessed at pre-screening

• Patient is currently engaged in clinician-administered therapy

Assessed at baseline (clinician interview)

* Patient is not clinically appropriate for outpatient level of care.
* Acute risk for suicidal thoughts or behaviors, assessed by the Columbia Suicide Severity Rating Scale, administered by research clinician at baseline.

About the study

Less than 20% of people with PTSD receive any treatment. This study extends a program of research by the investigator focused on developing adaptive (stepped) interventions for PTSD. The adaptive intervention sequences a digital mental health intervention (DMHI) and brief trauma- and skills-focused treatments for PTSD. The selected treatments are brief and scalable and less burdensome to systems of care. These treatments are: web-administered Skills Training in Affective and Interpersonal Regulation (webSTAIR), Brief STAIR, and Written Exposure Therapy (WET).

What is being tested

• webSTAIR (behavioral)
• WebSTAIR plus coaching (behavioral)
• Clinician administered Brief STAIR (behavioral)
• Clinician administered WET (behavioral)

Sponsor: Boston Medical Center · Participants: 428 · Started: Mar 12, 2026

Contact the study team

• Sarah Valentine, PhD · Phone: 857 264 1102

Official record on ClinicalTrials.gov — NCT06947538

Locations in the U.S.

Conditions

• Post-Traumatic Stress Disorder

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.