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At Home Ammonia Monitoring of Inborn Errors of Ammonia Metabolism
Pilot Study of At Home Ammonia Monitoring in Patients With an Inborn Error of Ammonia Metabolism
Who can join
Ages 12 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Confirmed ammonia disorder such as * Ornithine transcarbamylase deficiency * Systemic primary carnitine deficiency * Type I citrullinemia * Argininosuccinic aciduria * Isolated methylmalonic acidemia * Type II citrullinemia * Propionic acidemia * Isovaleric acidemia * Multiple acyl-CoA dehydrogenase deficiency * Pyruvate carboxylase deficiency * Argininemia (arginase deficiency) * Carbamoyl phosphate synthase I deficiency * Dihydrolipoamide dehydrogenase deficiency * Lysinuric protein intolerance * Hyperornithinemia-hyperammonemia-homocitrullinuria * Carnitine-acylcarnitine translocase deficiency * Carbonic anhydrase VA deficiency * N-acetyl glutamate synthetase deficiency * English Literacy Exclusion Criteria: * Incarcerated * Presence of a non-inborn error of metabolism medical condition associated with abnormal ammonia metabolism (e.g., end stage liver disease). * Unable to read in English
About the study
The goal of this observational study is to learn if people with certain ammonia metabolism disorders will measure their ammonia levels at home.
The main question it aims to answer is:
• Will participants measure their ammonia every day?
Participants will be asked to:
* Attend two in-person study visits at the clinic. * Measure temperature, heart rate, and blood oxygen every day. * Complete a short survey every day. * Measure ammonia every day.
What is being tested
- Ammonia Study Device (diagnostic test)
Sponsor: Sequitur Health Corp. · Participants: 30 · Started: Sep 23, 2025
Contact the study team
- Marylaura Thomas, Ph.D. · Phone: 1-855-445-3889
Official record on ClinicalTrials.gov — NCT06953505
Locations in the U.S.
| Oregon | Oregon Health & Science University, Portland |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.