Home › Post-Traumatic Stress Disorder › NCT06957067

Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Veterans interested in outpatient VA psychotherapy for PTSD
* Meets DSM-5 criteria for PTSD
* Be able to provide informed consent
* Be willing to be randomized
* Agree to not receive non-study psychotherapy for PTSD during study treatment (case management, supportive therapy/group, and concurrent substance use treatment are allowable)

Exclusion Criteria:

* Severe cognitive impairment
* Current suicidal or homicidal intent with a specific plan
* Uncontrolled psychotic or manic symptoms
* A psychiatric medication change in the past month
* A severe SUD as diagnosed by the DSM-5

About the study

Investigators' overall objective is to compare methods of identifying individuals who may be experiencing challenges in Cognitive Processing Therapy (CPT) and compare methods of intervening to optimize treatment retention and outcomes. Investigators' specific aims are:

1. to determine whether the use of CPT skills versus collaboratively considering switching to Present Centered Therapy (PCT) is more effective in improving outcomes for individuals experiencing challenges with CPT. Outcomes include post-traumatic stress disorder (PTSD) severity \[primary\], depression, functioning, and treatment retention; 2. to compare two approaches to identifying individuals in CPT in need of additional support during treatment; 3. to study the barriers and facilitators of implementing these intervention strategies.

Finally, exploratory aims will examine the stability of differences between treatment conditions, compare combinations of interventions tested, and examine moderators of intervention effects.

What is being tested

• CPT Skills (behavioral)
• Cognitive Processing Therapy (behavioral)
• Present Centered Therapy (behavioral)
• Shared Decision Making (behavioral)
• Measurement Based Care (behavioral)

Sponsor: United States Department of Defense · Participants: 280 · Started: Mar 17, 2025

Contact the study team

• Emily M Hudson, PhD · Phone: 612-629-7262
• Donald Lemon · Phone: (612) 467-1957

Official record on ClinicalTrials.gov — NCT06957067

Locations in the U.S.

Conditions

• Post-Traumatic Stress Disorder

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.