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Exercise-based Frailty Intervention in Lung Transplantation (XFIT)

An eXercise-based Frailty Intervention in Lung Transplantation (XFIT): A Phase Ib Clinical Trial Focused on Establishing Safety

Who can join

Ages 18 to 75 · All sexes

Group 1

Inclusion Criteria:

* Age 18 - 65 years
* Lung Transplant Candidates
* Speaks English or Spanish
* ≤ 8LPM O2 on 6MWT
* SPPB score ≤ 10

Exclusion Criteria:

* Lives Alone
* BMI \< 18.0 kg/m2
* Engaged in clinical pulmonary rehabilitation program
* Severe pHTN (RHC mPAP ≥ 30 mmHg or TTE PASP ≥ 60mmHg or moderately/severely reduced RV systolic function on TTE
* Deemed unsafe by site PI

Group 2

Inclusion Criteria:

* Age 18 - 75 years
* Speaks English or Spanish
* ≤ 15LPM O2 on 6MWT
* SPPB score ≤ 10

Exclusion Criteria:

* Lives Alone
* BMI \< 18.0 kg/m2
* Engaged in clinical pulmonary rehabilitation program
* Severely reduced RV systolic function on TTE
* Deemed unsafe by site PI

About the study

The goal of XFIT study is to measure the safety of an 8-week telehealth-delivered exercise and behavioral training program to treat frailty in lung transplant candidates in their own home. The main questions XFIT aims to answer are:

* Is XFIT safe? * Is XFIT feasible and acceptable by participants? * Is XFIT effective in improving frailty and physical function as reflected in patient-reported outcomes.

Participants will:

\- Participate in the 8-week XFIT program or enhanced standard of care

What is being tested

• XFIT (behavioral)

Sponsor: University of California, San Francisco · Participants: 70 · Started: Oct 22, 2026

Contact the study team

• Legna Betancourt · Phone: 415-476-8073

Official record on ClinicalTrials.gov — NCT06960421

Locations in the U.S.

Conditions

• Frailty

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.