Home › Prediabetes › NCT06967558
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
Who can join
Ages 25 to 70 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * People with stable weight and no history of diabetes. * Fasting glucose \< 126 mg/dL * 2hr glucose after 75g OGTT \< 200 mg/dL Exclusion Criteria: * Age \< 25 or \> 70 years (to avoid studying subjects who could have latent type 1 diabetes, or the effects of age extremes in subjects with normal or impaired fasting glucose). * HbA1c \> 6.5% * Use of any glucose-lowering agents including metformin or sulfonylureas. * For female subjects: positive pregnancy test at the time of enrollment or study * History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy. * Active systemic illness or malignancy. * Symptomatic macrovascular or microvascular disease.
About the study
We recently demonstrated that blockade of Glucagon-Like Peptide-1's (GLP-1) receptor (GLP1R) results in changes in islet function without changes in circulating GLP-1. These effects are more pronounced in people with early type 2 diabetes (T2DM) in keeping with increased expression of PC-1/3 and GLP-1 that is observed in diabetic islets. However, its regulation is at present unknown. At present it is unknown if these abnormalities develop in prediabetes and whether they contribute to the phenotypes observed. In this experiment we will use blockade of GLP1R to probe the contribution of endogenous GLP-1 secretion to the regulation of fasting glucose and islet function in prediabetes.
What is being tested
- Exendin 9-39 (biological)
- Saline (biological)
Sponsor: Mayo Clinic · Participants: 60 · Started: Nov 1, 2025
Contact the study team
- Adrian Vella, MD · Phone: 507-255-6515
Official record on ClinicalTrials.gov — NCT06967558
Locations in the U.S.
| Minnesota | Mayo Clinic in Rochester, Rochester |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.