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PET/MRI/EEG Imaging Study in Epilepsy

Investigation of Interictal Metabolic and Electrophysiologic Changes in Epilepsy Through Trimodal Neuroimaging

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Age 18 or older

Additional Inclusion Criteria for Subjects with Epilepsy:

* Diagnosed with epilepsy with abnormal interictal EEG

Exclusion Criteria:

* Contraindications to PET, MRI, or EEG imaging
* History of severe brain disease such as stroke and head trauma
* History of brain surgery
* History of type I or II diabetes mellitus
* Fasting plasma glucose level \>200 mg/dL
* Employed under direct supervision of the PI conducting the research

Additional Exclusion Criteria for Healthy Subjects:

* Current use of drugs that modulate brain function
* Current or past history of major medical, neurological, or psychiatric conditions

About the study

This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography \[FDG-PET\], and blood flow, measured by functional magnetic resonance imaging \[fMRI\]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography \[EEG\]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.

What is being tested

• FDG-PET/fMRI/EEG imaging (radiation)

Sponsor: Massachusetts General Hospital · Participants: 30 · Started: Sep 21, 2023

Contact the study team

• Magdelena S Allen, BA · Phone: 617-724-9232

Official record on ClinicalTrials.gov — NCT06974305

Locations in the U.S.

Conditions

• Epilepsy

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.