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Epilepsy clinical trials recruiting in the U.S.
101 studies for Epilepsy are recruiting participants at sites across the United States.
Epilepsy is a brain disorder that causes people to have seizures. The seizures may be mild or severe. Learn about causes, diagnosis, and treatment.
Cities with the most studies
- Boston, MA20 studies
- Houston, TX16 studies
- New York City, NY14 studies
- Washington, DC13 studies
- Philadelphia, PA12 studies
- Phoenix, AZ10 studies
- Cleveland, OH9 studies
- Mountain View, CA8 studies
- Rochester, MN8 studies
- St. Louis, MO8 studies
- Miami, FL8 studies
- Durham, NC8 studies
- Cincinnati, OH7 studies
- Jacksonville, FL7 studies
- Birmingham, AL7 studies
- Nashville, TN7 studies
- Los Angeles, CA7 studies
- Chicago, IL6 studies
- Aurora, CO6 studies
- Charlotte, NC5 studies
- Columbus, OH5 studies
- Dallas, TX5 studies
- Clifton, NJ5 studies
- Boise, ID5 studies
- Pittsburgh, PA5 studies
- Ann Arbor, MI4 studies
- Tampa, FL4 studies
- New Haven, CT4 studies
- Minneapolis, MN4 studies
- Little Rock, AR4 studies
- Orange, CA4 studies
- Detroit, MI4 studies
- Baltimore, MD4 studies
- Akron, OH4 studies
- Tucson, AZ4 studies
- San Diego, CA4 studies
- Salt Lake City, UT4 studies
- Sacramento, CA3 studies
- Portland, OR3 studies
- Kansas City, KS3 studies
By state
- Alabama9 studies
- Arizona11 studies
- Arkansas5 studies
- California21 studies
- Colorado7 studies
- Connecticut4 studies
- Florida14 studies
- Georgia5 studies
- Idaho5 studies
- Illinois8 studies
- Kansas3 studies
- Kentucky3 studies
- Maryland16 studies
- Massachusetts23 studies
- Michigan9 studies
- Minnesota11 studies
- Missouri9 studies
- New Hampshire6 studies
- New Jersey5 studies
- New York18 studies
- North Carolina12 studies
- Ohio19 studies
- Oregon3 studies
- Pennsylvania14 studies
- Tennessee8 studies
- Texas22 studies
- Utah4 studies
- Virginia4 studies
- Washington3 studies
- Wisconsin3 studies
Recently updated studies
Evaluation and Treatment of Neurosurgical Disorders
RecruitingObservational study
Ages 4 to 99 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT00060541Surgery as a Treatment for Medically Intractable Epilepsy
RecruitingObservational study
Ages 8 to 99 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT01273129Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy
RecruitingPhase 1
Ages 18 to 60 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT02531880Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07563881Modulating Movement Intention Via Cortical Stimulation
RecruitingHealthy volunteers welcome
Ages 18 to 65 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT03233399Investigating Epilepsy: Screening and Evaluation
RecruitingObservational study
Ages 8 to 110 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT03478852Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 120 ยท All sexes ยท Updated Sep 17, 2026 ยท NCT02107989Diagnosing Epilepsy To EffeCT Change
Recruiting
Ages 18 to 75 ยท All sexes ยท Updated Sep 15, 2026 ยท NCT07110337A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy
RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT06388707Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up
RecruitingObservational study
Ages 18 to 75 ยท All sexes ยท Updated Sep 15, 2026 ยท NCT07110454Prospective Natural History Study of POLG Disease
RecruitingObservational study
All ages ยท All sexes ยท Updated Sep 15, 2026 ยท NCT07775872SeizEAR Safety Study
RecruitingHealthy volunteers welcome
Ages 18 to 70 ยท All sexes ยท Updated Sep 14, 2026 ยท NCT07088835Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Sep 2, 2026 ยท NCT07594119Tumor Related Epilepsy
RecruitingObservational study
Ages 8 to 99 ยท All sexes ยท Updated Aug 28, 2026 ยท NCT02639325Physiological Brain Atlas Development
RecruitingObservational study
Ages 6 to 90 ยท All sexes ยท Updated Aug 26, 2026 ยท NCT00575081A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
RecruitingPhase 2/3
Ages 18 to 75 ยท All sexes ยท Updated Aug 24, 2026 ยท NCT06132893AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
RecruitingPhase 1/2
Ages 18 to 75 ยท All sexes ยท Updated Aug 24, 2026 ยท NCT06063850Brain Development Research Program
RecruitingObservational study
All ages ยท All sexes ยท Updated Aug 17, 2026 ยท NCT00305305Subcortical Arousal in Perceptual Awareness
Recruiting
Ages 13 and older ยท All sexes ยท Updated Aug 10, 2026 ยท NCT06934356A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
RecruitingPhase 3
Ages 12 and older ยท All sexes ยท Updated Aug 10, 2026 ยท NCT05667142Implementation and Cost Evaluation of Project UPLIFT
Recruiting
Ages 18 and older ยท All sexes ยท Updated Aug 7, 2026 ยท NCT06865820Sleep Architecture & Cognition in Focal Epilepsy
Recruiting
Ages 18 to 40 ยท All sexes ยท Updated Aug 7, 2026 ยท NCT05794295Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut Syndrome
RecruitingObservational study
Up to age 26 ยท All sexes ยท Updated Aug 6, 2026 ยท NCT05374824Outcomes After Planned Discontinuation of AntiSeizure Medication
RecruitingPhase 4
Ages 18 and older ยท All sexes ยท Updated Aug 6, 2026 ยท NCT07750496A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety
RecruitingPhase 3
1 Day โ 18 Years ยท All sexes ยท Updated Aug 3, 2026 ยท NCT07019922From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.