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Epilepsy clinical trials recruiting in the U.S.

102 studies for Epilepsy are recruiting participants at sites across the United States.

Epilepsy is a brain disorder that causes people to have seizures. The seizures may be mild or severe. Learn about causes, diagnosis, and treatment.

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Recently updated studies

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT07563881

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures

RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT07594119

Biomarker Targeted Stimulation for Epileptiform Events

Recruiting
Ages 7 and older ยท Men ยท Updated Nov 12, 2026 ยท NCT06424977

Tumor Related Epilepsy

RecruitingObservational study
Ages 8 to 99 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT02639325

Evaluation and Treatment of Neurosurgical Disorders

RecruitingObservational study
Ages 4 to 99 ยท All sexes ยท Updated Nov 10, 2026 ยท NCT00060541

Genetic Markers of Cardiovascular Disease in Epilepsy

RecruitingObservational study
Ages 18 to 50 ยท All sexes ยท Updated Nov 3, 2026 ยท NCT02824822

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

RecruitingPhase 3
Ages 12 and older ยท All sexes ยท Updated Nov 2, 2026 ยท NCT05667142

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Nov 2, 2026 ยท NCT05716100

HOBSCOTCH-YOUTH and Young Adults

Recruiting
Ages 13 to 29 ยท All sexes ยท Updated Nov 2, 2026 ยท NCT07735715

Mapping of Human Cognition

Recruiting
Ages 18 to 75 ยท All sexes ยท Updated Nov 2, 2026 ยท NCT05989893

Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))

RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Oct 30, 2026 ยท NCT05135091

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

RecruitingPhase 1
Ages 18 to 60 ยท All sexes ยท Updated Oct 29, 2026 ยท NCT02531880

PET/MRI/EEG Imaging Study in Epilepsy

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Oct 28, 2026 ยท NCT06974305

Epilepsy Seizure Detection With Innovative Tripolar EEG (tEEG)

RecruitingObservational study
Ages 6 and older ยท All sexes ยท Updated Oct 27, 2026 ยท NCT05944692

Diagnosing Epilepsy To EffeCT Change

Recruiting
Ages 18 to 75 ยท All sexes ยท Updated Oct 26, 2026 ยท NCT07110337

Surgery as a Treatment for Medically Intractable Epilepsy

RecruitingObservational study
Ages 8 to 99 ยท All sexes ยท Updated Oct 26, 2026 ยท NCT01273129

Investigating Epilepsy: Screening and Evaluation

RecruitingObservational study
Ages 8 to 110 ยท All sexes ยท Updated Oct 26, 2026 ยท NCT03478852

Optimizing Brain Stimulation Parameters

Recruiting
Ages 6 and older ยท All sexes ยท Updated Oct 26, 2026 ยท NCT06617845

Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up

RecruitingObservational study
Ages 18 to 75 ยท All sexes ยท Updated Oct 22, 2026 ยท NCT07110454

EXercise-induced PhysioLogical Adaptations In Neurological Disorders

RecruitingHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Oct 20, 2026 ยท NCT07883720

Artificial Intelligence for Brain MRI Analysis in Epilepsy

RecruitingObservational study
All ages ยท All sexes ยท Updated Oct 19, 2026 ยท NCT07881185

Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database

RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 120 ยท All sexes ยท Updated Oct 19, 2026 ยท NCT02107989

Sleep-Sensitive Seizure Risk Assessment With Wearable EEGs

Recruiting
Ages 18 and older ยท All sexes ยท Updated Oct 19, 2026 ยท NCT06545643

Overnight TI in TLE

Recruiting
Ages 18 to 70 ยท All sexes ยท Updated Oct 16, 2026 ยท NCT07434986

Post-Market Real-World Evidence Registry for the NeuroOne OneRFยฎ Ablation System for Epilepsy

RecruitingObservational study
All ages ยท All sexes ยท Updated Oct 16, 2026 ยท NCT07546253

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.