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Epilepsy clinical trials recruiting in the U.S.
102 studies for Epilepsy are recruiting participants at sites across the United States.
Epilepsy is a brain disorder that causes people to have seizures. The seizures may be mild or severe. Learn about causes, diagnosis, and treatment.
Cities with the most studies
- Boston, MA18 studies
- Houston, TX15 studies
- New York City, NY14 studies
- Washington, DC13 studies
- Philadelphia, PA12 studies
- Durham, NC9 studies
- Phoenix, AZ9 studies
- Rochester, MN9 studies
- Cleveland, OH9 studies
- Miami, FL8 studies
- Birmingham, AL7 studies
- Mountain View, CA6 studies
- Dallas, TX6 studies
- Jacksonville, FL6 studies
- Nashville, TN6 studies
- San Diego, CA5 studies
- Minneapolis, MN5 studies
- Charlotte, NC5 studies
- St. Louis, MO5 studies
- Los Angeles, CA5 studies
- Cincinnati, OH4 studies
- Chicago, IL4 studies
- Aurora, CO4 studies
- Ann Arbor, MI4 studies
- Detroit, MI4 studies
- Pittsburgh, PA4 studies
- Orange, CA4 studies
- Baltimore, MD4 studies
- Boise, ID4 studies
- Clifton, NJ4 studies
- San Francisco, CA4 studies
- New Haven, CT3 studies
- Tampa, FL3 studies
- Kansas City, KS3 studies
- Springfield, IL3 studies
- Austin, TX3 studies
- Columbus, OH3 studies
- Orlando, FL3 studies
- Atlanta, GA3 studies
- Akron, OH3 studies
By state
- Alabama8 studies
- Arizona10 studies
- Arkansas3 studies
- California20 studies
- Colorado5 studies
- Connecticut3 studies
- Florida14 studies
- Georgia4 studies
- Idaho4 studies
- Illinois7 studies
- Kansas3 studies
- Maryland16 studies
- Massachusetts21 studies
- Michigan9 studies
- Minnesota11 studies
- Missouri6 studies
- New Hampshire7 studies
- New Jersey5 studies
- New York17 studies
- North Carolina12 studies
- Ohio15 studies
- Oregon3 studies
- Pennsylvania14 studies
- Tennessee7 studies
- Texas21 studies
- Utah3 studies
- Virginia3 studies
Recently updated studies
Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT07563881Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT07594119Biomarker Targeted Stimulation for Epileptiform Events
Recruiting
Ages 7 and older ยท Men ยท Updated Nov 12, 2026 ยท NCT06424977Tumor Related Epilepsy
RecruitingObservational study
Ages 8 to 99 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT02639325Evaluation and Treatment of Neurosurgical Disorders
RecruitingObservational study
Ages 4 to 99 ยท All sexes ยท Updated Nov 10, 2026 ยท NCT00060541Genetic Markers of Cardiovascular Disease in Epilepsy
RecruitingObservational study
Ages 18 to 50 ยท All sexes ยท Updated Nov 3, 2026 ยท NCT02824822A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
RecruitingPhase 3
Ages 12 and older ยท All sexes ยท Updated Nov 2, 2026 ยท NCT05667142A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Nov 2, 2026 ยท NCT05716100HOBSCOTCH-YOUTH and Young Adults
Recruiting
Ages 13 to 29 ยท All sexes ยท Updated Nov 2, 2026 ยท NCT07735715Mapping of Human Cognition
Recruiting
Ages 18 to 75 ยท All sexes ยท Updated Nov 2, 2026 ยท NCT05989893Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Oct 30, 2026 ยท NCT05135091Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy
RecruitingPhase 1
Ages 18 to 60 ยท All sexes ยท Updated Oct 29, 2026 ยท NCT02531880PET/MRI/EEG Imaging Study in Epilepsy
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Oct 28, 2026 ยท NCT06974305Epilepsy Seizure Detection With Innovative Tripolar EEG (tEEG)
RecruitingObservational study
Ages 6 and older ยท All sexes ยท Updated Oct 27, 2026 ยท NCT05944692Diagnosing Epilepsy To EffeCT Change
Recruiting
Ages 18 to 75 ยท All sexes ยท Updated Oct 26, 2026 ยท NCT07110337Surgery as a Treatment for Medically Intractable Epilepsy
RecruitingObservational study
Ages 8 to 99 ยท All sexes ยท Updated Oct 26, 2026 ยท NCT01273129Investigating Epilepsy: Screening and Evaluation
RecruitingObservational study
Ages 8 to 110 ยท All sexes ยท Updated Oct 26, 2026 ยท NCT03478852Optimizing Brain Stimulation Parameters
Recruiting
Ages 6 and older ยท All sexes ยท Updated Oct 26, 2026 ยท NCT06617845Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up
RecruitingObservational study
Ages 18 to 75 ยท All sexes ยท Updated Oct 22, 2026 ยท NCT07110454EXercise-induced PhysioLogical Adaptations In Neurological Disorders
RecruitingHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Oct 20, 2026 ยท NCT07883720Artificial Intelligence for Brain MRI Analysis in Epilepsy
RecruitingObservational study
All ages ยท All sexes ยท Updated Oct 19, 2026 ยท NCT07881185Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 120 ยท All sexes ยท Updated Oct 19, 2026 ยท NCT02107989Sleep-Sensitive Seizure Risk Assessment With Wearable EEGs
Recruiting
Ages 18 and older ยท All sexes ยท Updated Oct 19, 2026 ยท NCT06545643Overnight TI in TLE
Recruiting
Ages 18 to 70 ยท All sexes ยท Updated Oct 16, 2026 ยท NCT07434986Post-Market Real-World Evidence Registry for the NeuroOne OneRFยฎ Ablation System for Epilepsy
RecruitingObservational study
All ages ยท All sexes ยท Updated Oct 16, 2026 ยท NCT07546253From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.