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The Benefits Of Cryoablation In Patients Undergoing Total Knee Arthroplasty

The Benefits Of Cryoablation In Patients Undergoing Total Knee Arthroplasty - A Randomized Prospective Clinical Trial

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Patients are candidates for elective primary total knee arthroplasty for a diagnosis of osteoarthritis or inflammatory arthritis.
* Patients have been medically cleared and scheduled for surgery

Exclusion Criteria:

* Patients with cold-related conditions (cryoglobulinemia, paroxysmal cold hemoglobinuria, cold urticaria, and Raynaud's disease)
* Surgery for fracture, infection, or malignancy

About the study

The purpose of this study is to evaluate the efficacy of cryoablation use on patient-reported outcomes (PROMs) and opioid consumption following total knee arthroplasty. This is a randomized study that will involve a 1:1 randomization to total knee arthroplasty +/- cryoablation.

What is being tested

• Total knee arthroplasty (TKA) (procedure)
• Cryoablation (device)

Sponsor: NYU Langone Health · Participants: 215 · Started: Jun 13, 2025

Contact the study team

• Daniel Waren · Phone: 212-598-6245

Official record on ClinicalTrials.gov — NCT06991231

Locations in the U.S.

Conditions

• Pain After Surgery

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.