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A Study of the MIND Diet for Persons With Multiple Sclerosis
Randomized Controlled Trial of MIND Diet for Neuroprotection and Symptom Management in MS
Who can join
Ages 18 to 70 · All sexes
Full eligibility criteria
Inclusion Criteria: * Ages 18-70 years, inclusive * MS diagnosis, on any treatment (including no treatment) * MIND diet score of ≤8 at baseline * NfL parameters determined by age Exclusion Criteria: * Diagnosis of an additional neurodegenerative disease (e.g. Alzheimer's) or other serious neurological condition (e.g. stroke) * Current serious medical condition that could impact the ability to participate or influence study results (e.g. cancer, HIV) * Pregnancy/planning during study period
About the study
This study will assess the impact of a MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet on brain health and MS symptoms. Participants will be randomly assigned to one of two arms: the diet intervention arm or the "continue current diet"/control arm. Participants randomized to the dietary intervention arm will change their diet to follow a MIND dietary pattern for one year; diet-related education and programming is provided to support this change. Participants randomized to the continue/control arm will be asked to continue their current dietary habits, without major change for one year; multiple sclerosis (MS) MS-related related education and programming (unrelated to diet) is provided. All participants will be asked to provide blood \& stool samples and to complete online questionnaires \& three in-person assessments.
What is being tested
- Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet (behavioral)
- Small Group (behavioral)
Sponsor: Icahn School of Medicine at Mount Sinai · Participants: 100 · Started: May 12, 2025
Contact the study team
- Claire E Wigley, Bsc, BSPH · Phone: (212) 241-3759
- Susan Filomena · Phone: 212-241-3841
Official record on ClinicalTrials.gov — NCT06992115
Locations in the U.S.
| New York | Mount Sinai Hospital, New York |
Conditions
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.