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Smart Olfaction App to Reduce Relapse
An Innovative Digitally-Delivered Olfactory Method for Reducing Cigarette Cravings and Supporting Smoking Cessation
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * At least 18 years of age * Ability to read, understand and speak English * Currently smoke at least 5 cigarettes daily for one year or longer * Do not currently smoke marijuana or currently smoke marijuana but willing to not smoke during the duration of the study * Did not use electronic cigarette or vaping device in the past 90 days * Have an active smartphone that is Apple or Android based * Have phone service including a data plan * Interested in downloading the study app onto their personal phone * Motivated to quit smoking * English literacy of 7th grade or higher, as indicated by a score of ≥ 4 on the Rapid Estimate of Adult Literacy in Medicine-Short Form (REALM-SF) * Biochemical verification of smoking status * Proof of smoking status at enrollment via photo of cigarettes * Presents a photo ID that matches the information on screener survey * Willing and able to complete study procedures * Willing to use NRT and quit smoking for 14 days (Phase I) or willing to use NRT and quit smoking for 13 weeks (Phase II) Exclusion Criteria: * Olfactory dysfunction including inability to smell, a very weak or distorted sense of smell, or sensitivity to odors * Report any allergies or negative reactions to odors/fragranced products * Being pregnant, breastfeeding, or planning to become pregnant within the next month * Report hypertension that is not under control * Have had a heart attack within the past two weeks * Those who participated in Phase I will not be eligible to participate in Phase II * Have a smartphone that is not compatible with the Insight mHealth platform * Report using electronic cigarette or vaping device in the past 90 days
About the study
The proposed project aims to refine and test a novel biobehavioral smoking cessation intervention that integrates the strategic application of olfactory stimulation to reduce cigarette craving with an established smartphone-based smoking cessation application. The specific aims of this study are: (1) refine the design and methodology of our olfactory stimulation delivery system (OSDS) and (2) compare, in a pilot randomized controlled trial (RCT), the effects of a smartphone based app for smoking cessation (Smart-T) with and without the OSDS on smoking cessation outcomes.
What is being tested
- Ad Libitum Use followed by Instructed Use of the Inspire Device (device)
- Instructed Use followed by Ad Libitum Use of the Inspire Device (device)
- Smart-T Smoking Cessation App with the Inspire Device Condition (device)
- Smart-T Smoking Cessation App Without the Inspire Device Condition (device)
- Nicotine replacement therapy (NRT) (drug)
- Inspire Device (device)
Sponsor: University of Houston · Participants: 132 · Started: Apr 22, 2026
Contact the study team
- Lorra Garey, Ph.D. · Phone: 713-743-8056
- Michael Businelle, Ph.D. · Phone: 405-271-8001
Official record on ClinicalTrials.gov — NCT07007195
Locations in the U.S.
| Texas | RESTORE Laboratory: Research on Emotion, Substance Use Treatment Outcomes, Rehabilitation, and Empowerment, Houston |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.