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Smart Olfaction App to Reduce Relapse

RecruitingEarly phase 1Healthy volunteers welcome

An Innovative Digitally-Delivered Olfactory Method for Reducing Cigarette Cravings and Supporting Smoking Cessation

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* At least 18 years of age
* Ability to read, understand and speak English
* Currently smoke at least 5 cigarettes daily for one year or longer
* Do not currently smoke marijuana or currently smoke marijuana but willing to not smoke during the duration of the study
* Did not use electronic cigarette or vaping device in the past 90 days
* Have an active smartphone that is Apple or Android based
* Have phone service including a data plan
* Interested in downloading the study app onto their personal phone
* Motivated to quit smoking
* English literacy of 7th grade or higher, as indicated by a score of ≥ 4 on the Rapid Estimate of Adult Literacy in Medicine-Short Form (REALM-SF)
* Biochemical verification of smoking status
* Proof of smoking status at enrollment via photo of cigarettes
* Presents a photo ID that matches the information on screener survey
* Willing and able to complete study procedures
* Willing to use NRT and quit smoking for 14 days (Phase I) or willing to use NRT and quit smoking for 13 weeks (Phase II)

Exclusion Criteria:

* Olfactory dysfunction including inability to smell, a very weak or distorted sense of smell, or sensitivity to odors
* Report any allergies or negative reactions to odors/fragranced products
* Being pregnant, breastfeeding, or planning to become pregnant within the next month
* Report hypertension that is not under control
* Have had a heart attack within the past two weeks
* Those who participated in Phase I will not be eligible to participate in Phase II
* Have a smartphone that is not compatible with the Insight mHealth platform
* Report using electronic cigarette or vaping device in the past 90 days

About the study

The proposed project aims to refine and test a novel biobehavioral smoking cessation intervention that integrates the strategic application of olfactory stimulation to reduce cigarette craving with an established smartphone-based smoking cessation application. The specific aims of this study are: (1) refine the design and methodology of our olfactory stimulation delivery system (OSDS) and (2) compare, in a pilot randomized controlled trial (RCT), the effects of a smartphone based app for smoking cessation (Smart-T) with and without the OSDS on smoking cessation outcomes.

What is being tested

Sponsor: University of Houston · Participants: 132 · Started: Apr 22, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07007195

Locations in the U.S.

TexasRESTORE Laboratory: Research on Emotion, Substance Use Treatment Outcomes, Rehabilitation, and Empowerment, Houston

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.