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Comparing Surfactant Administration Through Supraglottic Airway and Thin Catheter for Preterm Infants
A Clinical Trial Comparing Surfactant Administration Through Supraglottic Airway or Thin Catheter for Preterm Infants
Who can join
0 Hours – 72 Hours · All sexes
Full eligibility criteria
Inclusion Criteria: * All preterm infants born between 29-36 weeks' gestation. * Infants with birthweight greater than or equal to 750 grams and admitted to the NICU on CPAP for respiratory support requiring at least FiO2 25% and qualify for LISA procedure Exclusion Criteria: * Infants who require intubation prior to surfactant therapy * Infants with known severe congenital anomalies (complex congenital heart disease, airway and central nervous system anomalies) * Infants whose birth weight is less than 750 grams or oropharynx unable to accommodate laryngeal mask airways
About the study
What is this study about? This study is comparing two ways of giving surfactant, a medicine that helps premature infants breathe better. Surfactant can be given using a thin tube ("Less Invasive Surfactant Administration", called the LISA method) or through a small airway device placed in the baby's throat above the vocal cords ("Surfactant Administration through Laryngeal or Supraglottic Airway", called the SALSA method). The goal is to see which method is safer and more effective for preterm infants who are born at 29-36 weeks of pregnancy and have trouble breathing.
What is the main question (hypothesis)? Infants who receive surfactant using the SALSA method will have fewer heart rate and breathing-related problems than those who receive it using the LISA method.
What are the aims? Aim 1: Are babies in the SALSA group less likely to have low heart rate or low oxygen levels during the procedure compared to babies in the LISA group? Aim 2: Do fewer babies in the SALSA group need to be put on a breathing machine within the first 72 hours of life? Aim 3: Does the SALSA method help reduce the overall time babies need breathing support and lower the cost of their care in the NICU?
What is being tested
- Surfactant Administration through Laryngeal or Supraglottic Airway (procedure)
- Surfactant Administration through Thin Catheter (procedure)
Sponsor: University of Texas Southwestern Medical Center · Participants: 40 · Started: Aug 5, 2026
Contact the study team
- Melody Chiu, M.D. · Phone: 214-648-3903
Official record on ClinicalTrials.gov — NCT07030270
Locations in the U.S.
| Texas | Parkland Health and Hospital Systems, Dallas |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.