Home › Pain › NCT07044323

Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment

Who can join

Ages 18 to 100 · All sexes

Inclusion Criteria:

* Age 18 -100
* Capacity to provide Informed Consent
* Unilateral above or below knee amputation more than 3 months prior to enrollment
* Absence of cognitive impairment, operationally defined as a Montreal Cognitive Assessment score of 18 or greater1.
* Pain averaged over the preceding 1 month in the phantom limb rated as greater than 4 on a scale of 0-10.

Exclusion Criteria:

* History of significant medical or neurological disorder such as stroke or moderate to severe traumatic brain injury (operationally defined as loss of consciousness for more than 30 minutes)
* History of significant or poorly controlled psychiatric disorders
* Substantial depression or anxiety affecting their ability to perform tasks necessary for the study.
* Current abuse of alcohol or drugs, prescription or otherwise
* Nursing a child, pregnant, or intent to become pregnant during the study

About the study

After amputation of an arm or leg, up to 90% of subjects experience a "phantom limb", a phenomenon characterized by persistent feelings of the missing limb. Many subjects with a phantom limb experience intense pain in the missing extremity that is often poorly responsive to medications or other interventions. The study will explore the feasibility and efficacy of a home-based, active VR treatment for phantom limb pain (PLP).

What is being tested

• Active Virtual Reality Treatment (behavioral)

Sponsor: Albert Einstein Healthcare Network · Participants: 44 · Started: Jun 16, 2025

Contact the study team

• Laurel Buxbaum · Phone: 215-663-6321

Official record on ClinicalTrials.gov — NCT07044323

Locations in the U.S.

Conditions

• Pain
• Phantom Limb

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.