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Personalized Brain Stimulation to Help Veterans Quit Smoking

Recruiting

Circuity-guided Repetitive Transcranial Magnetic Stimulation (rTMS) for Tobacco Use in Veterans: A Comparison of Insula-rTMS and Prefrontal-rTMS

Who can join

Ages 18 to 70 · All sexes

Full eligibility criteria
Inclusion Criteria:

* Veteran
* Individuals who smoke 10 or more cigarettes per day and have a CO level \> 10 ppm indicative of recent smoking
* Those who have not received substance abuse treatment within the previous 30 days
* Those who have been stable on psychotropic medications for at least three months
* For females, those who test non-pregnant and use adequate birth control
* Those who are willing to provide informed consent
* Those who can comply with protocol requirements and likely complete all study procedures
* Those who are motivated to quit smoking (based on responses of "very likely" or "somewhat likely" in the motivation questionnaire

Exclusion Criteria:

* Current moderate to severe substance use of any psychoactive substances other than nicotine or caffeine, as defined by DSM-V criteria
* Contraindications to MRI (e.g., metal in the skull, orbital or intracranial cavity, or claustrophobia)
* Contraindications to rTMS (history of a seizure or epilepsy)
* A history of autoimmune, endocrine, viral, or vascular disorders affecting the brain
* History or MRI evidence of neurological disorder that would lead to local or diffuse brain lesions or significant physical impairment
* Unstable cardiac disease, uncontrolled hypertension, severe renal or liver insufficiency, or sleep apnea
* Major Axis I disorders diagnosed according to DSM-V criteria, such as bipolar affective disorder, schizophrenia, dementia, or major depression

  * Regarding the Veteran population, the investigators will enroll smokers who have PTSD
* Current use of other forms of nicotine delivery, such as nicotine patches or electronic cigarettes
* Currently prescribed bupropion and/or varenicline

About the study

Cigarette smoking is a significant public health concern for Veterans. Encouraging smoking cessation continues to be a top priority for the Veterans' Administration as Veterans who use tobacco experience negative health effects, including cancer, heart disease, and mental disorders. Despite the efficacy of current evidence-based pharmacotherapies and psychotherapies for smoking cessation, alternative treatments are critically needed. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive form of brain stimulation, US FDA-approved for smoking cessation. In this protocol, the investigators propose comparing the two rTMS protocols (standard TMS vs. precision TMS) to find a better treatment parameter for smoking cessation in Veterans. Identifying an efficacious rTMS protocol would benefit Veterans who want to quit smoking.

What is being tested

Sponsor: VA Office of Research and Development · Participants: 56 · Started: Jul 1, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07050862

Locations in the U.S.

South CarolinaRalph H. Johnson VA Medical Center, Charleston, SC, Charleston

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.