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Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):

Recruiting

Who can join

Ages 18 to 85 · All sexes

Full eligibility criteria

Inclusion Criteria:

1. Informed consent
2. Age 18-85 years
3. High burden paroxysmal AF (≥1%)
4. Moderate-severe OSA (AHI ≥ 15)
5. Implanted device with atrial diagnostics
6. Enrolled in remote monitoring

Exclusion Criteria:

1. AF ablation \<6 months
2. Valvular abnormalities
3. Excessive daytime sleepiness in safety-critical jobs
4. Plans for ablation during study
5. Non-CPAP OSA treatment
6. Recent device implantation (\<6 months)
7. Central sleep apnea

About the study

A pilot N-of-1 randomized controlled trial evaluating the effectiveness of a personalized CPAP intervention in reducing atrial fibrillation (AF) burden and improving AF-related quality of life in patients with moderate to severe obstructive sleep apnea (OSA).

What is being tested

CPAP (device)

Sponsor: The Cleveland Clinic · Participants: 20 · Started: Aug 25, 2025

Contact the study team

Mina Chung, MD · Phone: 2164442290
Reena Mehra, MD · Phone: 216-272-7405

Official record on ClinicalTrials.gov — NCT07087587

Locations in the U.S.

Ohio	Cleveland Clinic, Cleveland
Washington	University of Washington, Seattle (Not yet recruiting)

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.