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A Randomized Controlled Trial of a Nutritional Intervention for Endometriosis

Recruiting

Who can join

Ages 18 to 45 · Women

Full eligibility criteria
Inclusion Criteria:

1. Provision of signed and dated informed consent form
2. Stated willingness to comply with all study visits, procedures, requirements, and availability for the duration of the study
3. Women with a surgical, imaging, or clinical diagnosis of endometriosis
4. Age 18-45 years
5. Stable health condition and medications for the past 3 months
6. Modified Biberoglu and Behrman (B\&B) pelvic pain score of at least 5/9
7. Willing to be randomly assigned to either an active or a control group
8. Agreement to adhere to Lifestyle Considerations throughout the study duration

Exclusion Criteria:

1. Smoking or drug abuse during the past six months
2. Alcohol consumption of more than 2 drinks per day or the equivalent, episodic increased drinking (e.g., more than 2 drinks per day on weekends), or a history of alcohol abuse or dependency followed by any current use
3. Already following a WFPB diet
4. Pregnant or breastfeeding, or plans of pregnancy within the study period
5. Hysterectomy or ovariectomy
6. Fibroids, ovarian cysts, pelvic inflammatory disease
7. Endocrine inflammatory conditions, such as Cushing's syndrome, Hashimoto's thyroiditis, Graves' disease, type 1 diabetes mellitus, and Addison's disease
8. Evidence of an eating disorder

About the study

This randomized, controlled study will investigate the efficacy of a dietary intervention for women with endometriosis. Participants will be randomly assigned to follow a whole food plant-based (intervention) diet or stay on their usual (control) diet for 12 weeks.

What is being tested

Sponsor: University of California, San Diego · Participants: 120 · Started: Nov 1, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07090096

Locations in the U.S.

CaliforniaUCSD Health, La Jolla

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.