CALM Study: Cardiomems Assisted Lvad Management

Inclusion Criteria:

* Age 21-85
* Status post HeartMate III Left Ventricular Assist Device Implantation
* Normally functioning left ventricular assist device as determined by device parameters
* Stable and ready to be discharged home
* 18 years of age or older at the time of left ventricular device implantation
* The patient provides written informed consent before starting any component of this clinical investigation

Exclusion Criteria:

* Current/ongoing fevers or constitutional symptoms
* Bilirubin greater than 2.5µmol/L, shock liver, or biopsy-proven liver cirrhosis
* Requiring dialysis or declared end stage renal disease
* Inability to complete written informed consent or a quality-of-life questionnaire
* Known active malignancy
* History of recurrent (\> 1) pulmonary embolism or deep vein thrombosis
* Unable to tolerate a right heart catheterization
* Major cardiovascular event (e.g., myocardial infarction, stroke) within 2 months of CardioMEMS implant
* Glomerular Filtration Rate (GFR) \<25 ml/min who are non-responsive to diuretic therapy
* Patients likely to undergo heart transplantation within 6 months of Screening Visit
* Congenital heart disease or mechanical right heart valve(s)
* Known coagulation disorders
* Hypersensitivity or allergy to aspirin, and/or clopidogrel
* Pregnant or considering pregnancy
* Required RV assist device and has severe right heart failure post LVAD implantation