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Preoperative Acetazolamide
Preoperative Acetazolamide for Improved Pain Control Following Laparoscopic Hysterectomy
Who can join
Ages 21 to 65 · Women
Full eligibility criteria
Inclusion Criteria: * Women * Ages 21-65 * undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without bilateral salpingoophorectomy * undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without cystoscopy Exclusion Criteria: * Allergy to acetazolamide or sulfonamides * Known electrolyte disturbances * Pregnancy * Kidney failure or creatinine \>1.5 * Diuretic or lithium use * Chronic obstructive pulmonary disease (COPD) or other lung disease * Central nervous system disorders * Liver disease * Glaucoma * Preoperative or chronic opioid use * Diagnosis of fibromyalgia * Preoperative shoulder pain * Conversion to laparotomy * Intraoperative bladder or bowel injury * Inability to understand or utilize visual analog scale * Undergoing concurrent reconstructive procedures
About the study
The goal of this randomized study looks at whether giving patients a medicine called acetazolamide (also called Diamox) before they have laparoscopic hysterectomy may decrease postoperative pain. Researchers will compare acetazolamide to a placebo or inactive drug, to see if acetazolamide helps the pain that may occur after surgery from the gas used in the abdomen during the laparoscopic procedure. Patients will be asked to rate their pain before surgery and after surgery through 24 hours.
What is being tested
- Acetazolamide 500 MG Extended Release Oral Capsule (drug)
- Placebo (drug)
Sponsor: Prisma Health-Upstate · Participants: 100 · Started: Oct 30, 2025
Contact the study team
- Patti Parker, BSN · Phone: 864-455-1510
- Paul Miller, MD · Phone: 864-455-1600
Official record on ClinicalTrials.gov — NCT07101250
Locations in the U.S.
| South Carolina | Prisma Health, Greenville |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.