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Autonomic Neural Blockade in Bariatric Surgery

Autonomic Neural Blockade During Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial Evaluating Pain and Nausea After Bariatric Surgery

Who can join

Ages 18 to 90 · All sexes

Inclusion Criteria:

* Individuals able and willing to consent and participate in all study activities
* Adults, ages 18-90
* All patients with severe obesity undergoing laparoscopic/robotic gastric bypass or sleeve gastrectomy

Exclusion Criteria:

* Patients taking opiates chronically
* Patients allergic to study medications
* Patients with any prior adverse reaction to ingredients included in the block
* Adults unable to consent
* Pregnant women
* Prisoners

About the study

The purpose of this research is to evaluate if autonomic nerve block (ANB- blocking pain and nausea signals) decreases pain and anti-nausea medication requirements as well as the experience of pain/nausea during the first 72 hours after sleeve gastrectomy or gastric bypass surgery. Participants will be randomly assigned either to the standard of care or the ANB group before surgery. As part of standard of care, in both groups, laparoscopic bariatric surgery will be initiated with local anesthetic injected into the abdominal wall. In the ANB group, participants will be given an additional injection of local anesthetic medication to block nerves on and around the stomach.

What is being tested

• Intraoperative autonomic neural blockade (ANB) (procedure)
• Laparoscopic Standard of Care Abdominal Wall Block (procedure)

Sponsor: Endeavor Health · Participants: 200 · Started: Feb 5, 2026

Contact the study team

• Herbert Hedberg, MD · Phone: 508-728-2106

Official record on ClinicalTrials.gov — NCT07104825

Locations in the U.S.

Conditions

• Pain After Surgery
• Postoperative Nausea and Vomiting

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.