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Initial Testing of a Behavioral Intervention About Genetic Services for Families at Risk of Lynch Syndrome
A Randomized Controlled Pilot Trial of a Behavioral Intervention to Increase Uptake of Genetic Services Among Relatives at Risk of Lynch Syndrome
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Probands Inclusion Criteria: * English speaking * at least 18 years old * have had genetic testing for Lynch syndrome (LS) * do not have a condition that would interfere with their ability to provide informed consent and complete study activities (e.g., cognitive dysfunction evaluated using clinical judgment during screening) Clinical Trial Participants Inclusion Criteria: * English-speaking * at least 18 years old * a blood relative of a patient who was diagnosed with LS * potentially at risk for LS * have not scheduled or had pre-test genetic counseling or genetic testing for LS * do not have a personal history of a cancer (excluding non-melanoma skin cancer) * do not have a condition that would interfere with their ability to provide informed consent and complete study activities (e.g., cognitive dysfunction evaluated using clinical judgment during screening)
About the study
The purpose of the study is to see if our education materials help people at risk for Lynch syndrome decide about seeking genetic services. Untested relatives of patients with Lynch syndrome will be recruited to complete a baseline survey and will be randomized to receive either the an information letter or an information letter plus a booklet. Two follow-up surveys will be administered over the span of 6 months. Participants will also be invited to join an optional exit interview to provide feedback.
What is being tested
- Information Letter and Booklet (behavioral)
- Information Letter (behavioral)
Sponsor: University of Alabama at Birmingham · Participants: 185 · Started: Sep 15, 2025
Contact the study team
- Haoyang Yan, PhD · Phone: 205-914-2249
- Kaylee Burgan, MS · Phone: 205-914-2249
Official record on ClinicalTrials.gov — NCT07106359
Locations in the U.S.
| Alabama | UAB, Birmingham |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.