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Exercise Adherence and Cognitive Decline: Phase 2

Exercise Adherence and Cognitive Decline: A Goal-setting and Exercise Intensity Intervention Collaboratively Developed With the Black Community

Who can join

Ages 45 to 65 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* \<3 incorrect responses on the Pfeiffer Mental Status Questionnaire
* Ages 45 to 65
* Consent to be randomized to conditions
* Planning to remain in the Denver metro area for the next 14 months
* Identify as Black or African American

Exclusion Criteria:

* Currently physically active (i.e., \>90 min/week of moderate PA or \>40 min/week of vigorous PA consistently for the past 6 months)
* On antipsychotic medications or currently under treatment for any serious psychiatric disorder including Alzheimer's or dementia
* Inability to walk 3 blocks without chest pain, shortness of breath, or lightheadedness
* Inability to climb 2 flights of stairs without chest pain, shortness of breath, or lightheadedness

PCP Exclusion Criteria:

* Answers "yes" to 1 or more of the 7 general questions of the PAR-Q+ and answers yes to any of the follow up questions.
* Blood pressure at baseline is greater than 160/100
* Blood pressure at baseline is between 140/90 - 160/100 and the participant is currently taking blood pressure medication
* Blood pressure \> 210/90 mmHg (for men) or \> 190/90 mmHg (for women) immediately after exercise

About the study

The purpose of this study is to conduct a test of a goals-based program to help people exercise more. This program was designed for individuals aged 45-65 from the Black community. Low levels of physical activity are related to health problems such as heart disease, diabetes, and cognitive decline. People of color are more negatively impacted by these conditions and have also historically been underrepresented by research seeking to increase physical activity. The investigators have developed this goals-based exercise promotion program with the help of a Black-led community-based organization (The Gyedi Project) and a Community Advisory Board made up of stakeholders in the Black community.

What is being tested

• Goal Setting and Exercise Intensity Intervention (behavioral)

Sponsor: University of Colorado, Boulder · Participants: 226 · Started: Nov 5, 2025

Contact the study team

• Soha Khadem, B.S. · Phone: 720-853-4676

Official record on ClinicalTrials.gov — NCT07127965

Locations in the U.S.

Conditions

• Mild Cognitive Impairment

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.